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A large literature exists on trabecular and cortical bone morphology. The engineering performance of bone, implied from its 3d architecture, is often the endpoint of bone biology experiments, being clinically relevant to bone fracture. How and why does bone travel along its complex spatio-temporal trajectory to acquire its architecture? The question "why" can have two meanings. The first, "teleological - why is an architecture advantageous?" – is the domain of substantial biomechanical research to date. The second, "etiological – how did an architecture come about?" – has received far less attention. This Frontiers Bone Research Topic invited contributions addressing this "etiological ...
Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and patholo...
These volumes differ from the current conventional texts on bone cell biology. Biology itself is advancing at breakneck speed and many presentations completely fail to present the field in a truly modern context. This text does not attempt to present detailed clinical descriptions. Rather, after discussion of basic concepts, there is a concentration on recently developed findings equally relevant to basic research and a modern understanding of metabolic bone disease. The book will afford productive new insights into the intimate inter-relation of experimental findings and clinical understanding. Modern medicine is founded in the laboratory and demands of its practitioners a broad scientific understanding: these volumes are written to exemplify this approach. This book is likely to become essential reading equally for laboratory and clinical scientists.
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Directory of information for public advisory committees and 4 agencies of the Public Health Service directly concerned with health care, health services, and related research activities. Committees are arranged under the offices or agencies, e.g., the National Institute of Mental Health has 30 committees listed thereunder. Each entry gives authority of the committee, structure, function, meetings, and members. Indexes of committees and individuals.
Osteoporosis Research - Animal Models, presents in a very illustrative and practical manner, general methodologies of bone studies in animals, as well as the particular features of the most commonly used animal models in the field. Research in the field of osteoporosis has grown in recent years. This has resulted in significant advances in determining the causes of osteoporosis, assessing risk factors, and creating new treatment methods. The use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. Osteoporosis Research - Animal Models, is an essential tool for researchers in the bone field. This book aids researchers in selecting their appropriate model and highlights the experiments that can be strategically designed to optimize the potential of an animal to develop the cardinal features of osteoporosis in humans. This book addresses the importance of recent findings from animal models and their significance on the pathogenesis of osteoporosis in relation to human disease.
Englishman Lake Benson loaned his life savings to his dippy sister so that she could buy a shop. It was a big mistake. His sister has been steadily flushing his money down the drain – and now he wants it back. Years in the special forces taught Lake that if you want a job done, do it yourself. So he steps in to make the shop profitable, sell it and get his money back. The only problem is, the business is an underwear shop. And all Lake knows about underwear can be summed up in how fast he can unsnap a bra. To make matters worse, the tiny highland town already has a lingerie shop. A successful one, run by an ex-lingerie model. A very gorgeous ex-lingerie model, who’s distracting him from ...
This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the g...
"It's irritating when romance gets in the way of your goals. And falling in lust with Jack Miller is definitely getting in the way of Davina's plans. Davina has a movie to make and an acting career to resurrect - okay, so it was never alive in the first place, but that's not the point. The point is: she's hitting thirty and she wants to be famous. And if that means making an indie movie with 'borrowed' film equipment and shooting the movie in Jack's house without permission - then so be it"--Publisher's website.
Dr. Julien Barthes is Collaborative Project Manager at PROTiP MEDICAL SAS. All other Topic Editors declare no competing interests with regards to the Research Topic subject.