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Chemistry, 1996-2000
A collection of the Nobel Lectures delivered by the prizewinners in chemistry, together with their biographies, portraits and the presentation speeches.
Membrane Structure and Mechanisms of Biological Energy Transduction
The problem of electron transfer phosphorylation was first formu lated in 1939 by Belitser and Tsibakova I who introduced the "P: 0" criterion and showed that this ratio is more than 1. The authors noted that such a high value of the phosphorylation coefficient suggests a fundamental difference in the mechanisms of A TP formation coupled with respiration, and glycolysis, since in the latter case, the amount of the ATP synthesized is equal to that of the substrate utilized. A lot of hypothetical schemes were put forward to explain the nature of coupling between electron transfer and phosphorylation, but none of them solved the problem. Only quite recently, one hypo thetical scheme of energy coupling, viz. Mitchell's chemiosmotic concept, 2.3 was supported by experimental data which allow us to prefer it to alternative possibilities. In this paper, I shall try to substantiate the statement that oxidation and phosphorylation can be coupled via a membrane potential as was postulated by Mitchell.
Membrane Transport
This is a fascinating collection of personal accounts which is a "must read" for anyone interested in membrane transport or the history of the development of the current picture of membrane transport physiology. This delightful book could serve variously as a history for investigators and historians or as a textbook for advanced students. No biology or medical library should be without it
In Search of the Physical Basis of Life
It is highly probable that the ability to distinguish between living and nonliving objects was already well developed in early prehuman animals. Cognizance of the difference between these two classes of objects, long a part of human knowledge, led naturally to the division of science into two categories: physics and chemistry on the one hand and biology on the other. So deep was this belief in the separateness of physics and biology that, as late as the early nineteenth century, many biologists still believed in vitalism, according to which living phenomena fall outside the confines of the laws of physics. It was not until the middle of the nineteenth century that Carl Ludwig, Hermann von He...
The Enzymes of Biological Membranes
In the first edition of The Enzymes of Biological Membranes. published in four volumes in 1976, we collected the mass of widely scattered information on membrane-linked enzymes and metabolic processes up to about 1975. This was a period of transition from the romantic phase of membrane biochemistry, preoccupied with conceptual developments and the general properties of membranes, to an era of mounting interest in the specific properties of membrane-linked enzymes analyzed from the viewpoints of modem enzymology. The level of sophistication in various areas of membrane research varied widely; the structures of cytochrome c and cytochrome b were known 5 to atomic detail, while the majority of ...
Membrane Transport
Membrane Transport
Moving Questions
This book describes a half century of research on cellular membrane transport and on metabolic energy capture and utilization. During this time-which begins in the late 1930s-the effort and imagination of various scientists overthrew reigning formulations, created novel explanatory models, and unified previously distinct experimental fields. My primary goal is to display the course of that research, showing how new experiments defined novel entities and processes, and how an encompassing field, bioenergetics, then emerged. A secondary goal is to present examples of mainstream biological research that illustrate how experimental results-seen as refutations, confirmations, and elabora tions-ca...
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Volume 47 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with inotropic steroids, with chemokines and their involvement in a wide range of inflam matory diseases, with the subclassification and nomenclature of ul- and Uz-adrenoceptors, with Chinese traditional medicine, with drug targets in the molecular pathogenesis of asthma, with cytokines and their therapeutic application in immunosuppression and immunostimulation, with alter native medicine and with the potential use of calcium blockers in psy chiatry. These reviews and the quotations of origin...
Ion Transport
Ion Transport is a collection of papers from the Smith Kline & French Research "Symposium on Ion Transport" held in Cambridge, on April 12-14, 1989. These papers focus on the plasma membrane, particularly on the three main classes of transporters, namely, pumps, exchangers, and channels. Some papers discuss the different experimental approaches from electrophysiological and ion flux measurements through pharmacology, molecular biology, electrostatics, and computer modeling. Other papers discuss the P-type cation pump, a class of ATP-driven ion pumps, which is determined from its subunit composition and from the results of the hydrolysis of ATP. Several papers explain the techniques used in i...
Current Topics in Bioenergetics
Current Topics in Bioenergetics, Volume 11 provides information pertinent to the ATP utilizing or synthesizing parts of the major bioenergetics reactions of cells. This book discusses the individual proteins comprising each of the energy-transducing ATPases and their organization into a functional structure. Organized into six chapters, this volume begins with an overview of the role of ATPases in the production and utilization of the H+ gradient from a genetic and biochemical viewpoint. This text then examines the ATPase associated with bacterial membranes, which is known to have an analogous function and a similar structure to that found in membranes of chloroplasts and mitochondria. Other chapters consider the composition and the biogenesis of chromaffin granules. This book discusses as well the models for the mode of action of peptide molecules. The final chapter deals with the various forms of energy transduction. This book is a valuable resource for biologists, physiologists, and pharmacologists.
