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The interconnectedness of genetics and susceptibility to disease, viral and non-viral inflammation, and the role of immunity and the development of autoimmunity is a fascinating and much discussed topic in cardiomyopathy. This publication constitutes the outcome of an ESRF meeting held together with the German Research Foundation. Clinical researchers, immunologists, virologists and molecular biologists provide the latest findings in their fields, advancing our understanding of what causes chronic viral and inflammatory cardiomyopathy, why it affects a subset of individuals while sparing the majority, how we can develop better therapies, and whether the disease can be prevented. Special emphasis is placed on the role of viruses in the aetiology and pathogenesis of cardiomyopathy. The editors are convinced that the broad spectrum covered by this state-of-the-art publication will be of exceptional value to its readers.
The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.
This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology. Foreword written by Jürgen Drews.
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This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology. Foreword written by Jürgen Drews.
Consists of the proceedings of the 8th-12th International Congress for Microbiological Standardization.
This edited collection offers in seventeen chapters the latest scholarship on book catalogues in early modern Europe. Contributors discuss the role that these catalogues played in bookselling and book auctions, as well as in guiding the tastes of book collectors and inspiring some of the greatest libraries of the era. Catalogues in the Low Countries, Britain, Germany, France and the Baltic region are studied as important products of the early modern book trade, and as reconstructive tools for the history of the book. These catalogues offer a goldmine of information on the business of books, and they allow scholars to examine questions on the distribution and ownership of books that would otherwise be extremely difficult to pursue. Contributors: Helwi Blom, Pierre Delsaerdt, Arthur der Weduwen, Anna E. de Wilde, Shanti Graheli, Ann-Marie Hansen, Rindert Jagersma, Graeme Kemp, Ian Maclean, Alicia C. Montoya, Andrew Pettegree, Philippe Schmid, Forrest C. Strickland, Jasna Tingle, Marieke van Egeraat, and Elise Watson.