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From exotic wild species inhabiting unfamiliar settings to elusive forms still unknown to science or thought to be extinct, the Felidae, better known as ‘cats’, have been reported in sightings from around the world. According to conventional wisdom, they do not exist, but mystery cats of all sizes have attracted increasing attention from naturalists and laypersons alike, and the evidence for these animals is becoming more substantial and increasingly difficult to deny. Now, one of the world’s leading cryptozoological investigators and field researchers offers a comprehensive field guide and overview of these mysterious cat-like creatures. Filled with photographs, comprehensive paintings, classifications, and hard evidence, this book offers an invaluable resource for those who wish to investigate these sightings further or simply enjoy the fascinating reports provided by others.
This book presents the comprehensive description of basic principles, methodologies, similarities and differences of nano-liposomes and -phytosomes. It focuses on the implications of these nano carriers in drug delivery and also includes detailed classification of nanoinonized drug particles, polymeric nanoparticles and hydrophobic nanoparticles. This book concludes with the biological, technical and study-design challenges of Nanopharmaceuticals and presents critical viewpoints of smart DNA nanostructures. The risk factors and regulatory concerns have also been kept in focus and the book includes the toxicity and application of different types of ionic liquids for humans and environment. It also critically describes characteristics, applications and regulatory gaps of nanoparticle-ionic liquid combined systems.
Today's global markets demand that companies of all sizes look to international markets for potential customers. The successive crises that have taken place in the last decade make the internationalization of companies essential. This situation is further aggravated in the case of SMEs, as surviving only from national markets is becoming increasingly difficult. Indeed, the economic sphere is in constant flux, which demands that companies have a great capacity for adaptation to face the new challenges of an ever more globalized and difficult market. In this context, new forms of business communication are emerging, especially through the web and new technologies. Digital marketing and the dis...
The Neuronal Doctrine recently reached its 100th year and together with the development of psychopharmacology by the middle of 20th century promoted spectacular developments in the knowledge of the biological bases of behavior. The overwhelming amount of data accumulated, forced the division of neuroscience into several subdisciplines, but this division needs to dissolve in the 21st century and focus on specific processes that involve diverse methodological and theoretical approaches. The chapters contained in this book illustrate that neuroscience converges in the search for sound answers to several questions, including the pathways followed by cells, how individuals communicate with each other, inflammation, learning and memory, the development of drug dependence, and approaches to explaining the processes that underlie two highly incapacitating chronic degenerative illnesses.
The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies.
"A Almanjarra" de Artur de Azevedo e Aluísio de Azevedo é um romance envolvente que mergulha nas complexidades sociais e culturais do Brasil no final do século XIX. A trama se desenvolve em torno da Almanjarra, uma propriedade rural, e dos conflitos entre seus habitantes. Os irmãos Azevedo, combinando suas habilidades literárias, exploram temas como o poder, a ambição, as relações interpessoais e as tensões entre o urbano e o rural. Com uma narrativa rica em detalhes e personagens profundos, o livro oferece uma crítica perspicaz das desigualdades sociais e das transformações econômicas da época. É uma obra essencial para compreender o contexto histórico e social do Brasil imperial.
This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
Este livro é sobre um modo de construir conhecimento a respeito da realidade baseado na teoria ator-rede, na etnografia de objetos técnico-científicos e na vontade de saber o que tais objetos falam sobre nós: sociedade científica e tecnológica. Os textos aqui reunidos procuram equacionar uma dúvida comum a todos os autores: como reunir o social em pesquisas ligadas à natureza, ao ecossistema, ao ambiente natural? E, afinal, o que temos como resultado do processo de busca de solução para essa questão? Os textos exemplificam como o que chamamos de “social” ou de “questões sociais” não é adicionado àquilo que nos habituamos a chamar de “natureza” ou “questões naturais”, simplesmente porque essas questões são indissociáveis desde a origem! O leitor está convidado a participar dos experimentos intelectuais dos autores e a duvidar, tal como cada um deles, de abismos dualistas com os quais todos nós estamos habituados a conviver, como, por exemplo, entre conceitos e contextos, fatos científicos e valores sociais, natureza e sociedade. Trata-se de um convite para verificar o quanto as escolhas epistemológicas são também políticas
O presente trabalho explora o surgimento da doutrina da funcionalidade ao abrigo do regime da concorrência desleal, e a extensão do seu âmbito de aplicação à tutela das marcas. Partimos da jurisprudência dos EUA que, ao longo de mais de cem anos, tem refletido sobre os interesses subjacentes à doutrina da funcionalidade e o aparecimento de novos tipos de sinais distintivos, até à conhecida decisão do Supreme Court no caso TraFfix. No regime europeu de marcas, iremos analisar a funcionalidade enquanto motivo absoluto de recusa ou de declaração de invalidade da marca de forma. Começando no processo de harmonização do regime de marcas na UE, iremos focar-nos na jurisprudência do TJUE, que continua a reconhecer a decisão no processo Philips como uma das mais importantes sobre a funcionalidade.
Collective arbitration in Europe, Ana Montesinos García Futuros da Arbitragem: os próximos 10 anos - Lisboa, Ángel Sánchez Freire Some first steps on the difficult road to a coherent class or collective arbitration regime in Europe? Portugal?s upcoming shareholder dispute regime, António Pedro Pinto Monteiro e Joana Macedo The Dispute Resolution Board, Christopher R. Seppälä Likely Future Developments in International Arbitration, Denys Hickey Basic framework of damages in arbitration, Jesús Almoguera Arbitragens Necessárias: ainda são «arbitragem»? O caso do Tribunal Arbitral do Desporto, João Lima Cluny Enforcement and challenges to emergency decisions, José Joaquín Caicedo Demoulin Tools that arbitrators can use to reach their decision. Recommendations about the decision-making process. Mark Kantor, Juliette Fortin, Jesus Almoguera Mediação e Cláusulas Escalonadas, Rodrigo Garcia da Fonseca