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Microbial Exopolysaccharides: From Genes to Applications
Microbial polysaccharides represent an attractive alternative to those from plants or macro algae. They can be produced from renewable sources including lignocellulosic waste streams. Their production does not depend on geographical constraints and/or seasonal limitations. Additionally the manipulation of biosynthetic pathways to enhance productivity or to influence the chemical polysaccharide composition is comparatively easy in bacteria. Microbial exopolysaccharides represents a valuable resource of biogenic and biodegradable polymers, suitable to replace petro based polymers in various technical applications. Furthermore, biocompatible exopolysaccharides are very attractive in medical app...
Microbial Production of High-Value Products
This edited volume emphasizes how microorganisms have become a reliable pillar of biotechnology. The authors discuss advances in synthetic biology and genetic engineering that have made it possible to reprogram the microbial cellular capabilities. This enables an economically viable production of high-value products at an industrial level. The first part of the book provides an overview of synthetic biology and genome editing tools for engineering microbial cell factories in modern fermentation. Readers also learn how high-throughput bioprocessing methods are used to recover and purify microbial products. The remaining parts of this book explore the implementation and challenges of these upstream and downstream processing techniques for manufacturing high-value products. Cost-effectiveness and quality-control are key factors, when discussing the production of low-molecular-weight products, biopharmaceuticals, biopolymers and protein-based nanoparticles. This book is a valuable resource for biotechnologists both in the industry and in academia.
Testing the Canon of Ancient Near Eastern Art and Archaeology
This book considers the "Greatest Hits" of ancient Near Eastern art and archaeology, including canonical objects, sites, and monuments from Egypt, the Levant, Turkey, Syria, Iraq, and Iran, from the prehistoric era through the Classical period. Gansell, Shafer, and their contributors investigate the factors that have made these historical artifacts so well known for so long. By questioning the canon, this book allows readers to better reflect on the range of ancientNear Eastern culture and revise the canon so it can accommodate new discoveries, represent the values of heritage communities, and remain relevant to contemporary and future audiences.
Control Theory of Infinite-Dimensional Systems
This book presents novel results by participants of the conference “Control theory of infinite-dimensional systems” that took place in January 2018 at the FernUniversität in Hagen. Topics include well-posedness, controllability, optimal control problems as well as stability of linear and nonlinear systems, and are covered by world-leading experts in these areas. A distinguishing feature of the contributions in this volume is the particular combination of researchers from different fields in mathematics working in an interdisciplinary fashion on joint projects in mathematical system theory. More explicitly, the fields of partial differential equations, semigroup theory, mathematical physics, graph and network theory as well as numerical analysis are all well-represented.
Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment
Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Biotechnology of Phosphate Solubilizing Microorganisms for Metabolites regulation: Present and Future
Phosphate Solubilizing Microorganisms (PSMs) are typical environmental microbes, which can transform insoluble phosphate into plant absorbable forms in soil. The metabolites of organic acid by PSM usually dominate the insoluble phosphate dissolution and phosphorus transformation in soil. The tricarboxylic acid cycle (TCA) is the main metabolic pathway of organic acids secretion by PSM. Genetic, enzyme, and fermentation engineering technology can significantly affect the TCA pathway, changing the type and quantity of organic acid secretion, hence greatly affecting the application of PSM. In the case of fungi, the enhanced oxalic acid secretion is conducive to lead remediation, while food fermentation engineering needs more citric acid. In addition, the above biotechnology also greatly impacts other metabolites of PSMs, such as phosphatases, degrading enzymes and volatile organic compounds, etc. Therefore, promoting the capacity of metabolism via biotechnology is a current challenge for PSM in the pathway of application in food fermentation, environmental remediation, agricultural production, and biocontrol of plant pathogens.
Signs from Silence
The monograph Signs from Silence: Ur of the first Sumerians tells the story of the Sumerian city of Ur at the beginning of the third pre-Christian millennium (c. 2,900–2,700). In terms of research focusing on the emergence of one of the first statehood foci of human history—the pristine state of ancient Mesopotamia—, the author takes up evidence on a critical phase of early Mesopotamian social development. At the beginning of the third pre-Christian millennium, the men and women of Ur took up actions that decided whether the material and spiritual heritage of the preceding Late Uruk cultural-development phase (c. 3,500–3,200), when the first state, organized religion, sciences and th...
Industrial Microbiology
Focusing on current and future uses of microbes as production organisms, this practice-oriented textbook complements traditional texts on microbiology and biotechnology. The editors have brought together leading researchers and professionals from the entire field of industrial microbiology and together they adopt a modern approach to a well-known subject. Following a brief introduction to the technology of microbial processes, the twelve most important application areas for microbial technology are described, from crude bulk chemicals to such highly refined biomolecules as enzymes and antibodies, to the use of microbes in the leaching of minerals and for the treatment of municipal and indust...
