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Molecular Genetics of Liver Neoplasia
Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.
Calico Joe
#1 NEW YORK TIMES BESTSELLER • A surprising and moving novel of fathers and sons, forgiveness and redemption, set in the world of Major League Baseball… “Grisham knocks it out of the park.”—The Washington Post It’s the summer of 1973, and Joe Castle is the boy wonder of baseball, the greatest rookie anyone has ever seen. The kid from Calico Rock, Arkansas, dazzles Chicago Cubs fans as he hits home run after home run, politely tipping his hat to the crowd as he shatters all rookie records. Calico Joe quickly becomes the idol of every baseball fan in America, including Paul Tracey, the young son of a hard-partying and hard-throwing New York Mets pitcher. On the day that Warren Tracey finally faces Calico Joe, Paul is in the stands, rooting for his idol but also for his dad. Then Warren throws a fastball that will change their lives forever. Don’t miss John Grisham’s new book, THE EXCHANGE: AFTER THE FIRM!
Liver Growth and Repair
Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that ...
