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Development of Biopharmaceutical Drug-Device Products
The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies have raised the bar for the development and manufacture of antibody-based products, expecting to see the use of Quality by Design (QbD) elements demonstrating an in-depth understanding of product and process based on sound science. Drug delivery systems have become an increasingly important part of the therapy and most...
In Vitro-In Vivo Correlations
This book represents the invited presentations and some of the posters presented at the conference entitled "In Vitro-In Vivo Relationship (IVIVR) Workshop" held in Sep tember, 1996. The workshop was organized by the IVIVR Cooperative Working Group which has drawn together scientists from a number of organizations and institutions, both academic and industrial. In addition to Elan Corporation, which is a drug delivery com pany specializing in the development of ER (Extended Release) dosage forms, the IVIVR Cooperative Working Group consists of collaborators from the University of Maryland at Baltimore, University College Dublin, Trinity College Dublin, and the University of Not tingham in th...
TRAC: Trends in Analytical Chemistry
Trends in Analytical Chemistry, Volume 5 focuses on the advancements of processes, technologies, automation, and applications of analytical chemistry. The selection first offers information on graphics programming for the IBM PC using FORTRAN, PASCAL, and C, including graphics hardware system software, assembly language routines, and high level interface. The text then elaborates on the place of affinity chromatography in the production and purification of biomolecules from cultured cells and zone electrophoresis in open-tubular capillaries. Discussions focus on column and instrument design, applications, affinity chromatography in protein production from cells, and economic aspects of produ...
The Purdue Alumnus
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Dayside Magnetosphere Interactions
Exploring the processes and phenomena of Earth's dayside magnetosphere Energy and momentum transfer, initially taking place at the dayside magnetopause, is responsible for a variety of phenomenon that we can measure on the ground. Data obtained from observations of Earth’s dayside magnetosphere increases our knowledge of the processes by which solar wind mass, momentum, and energy enter the magnetosphere. Dayside Magnetosphere Interactions outlines the physics and processes of dayside magnetospheric phenomena, the role of solar wind in generating ultra-low frequency waves, and solar wind-magnetosphere-ionosphere coupling. Volume highlights include: Phenomena across different temporal and s...
Space Physics and Aeronomy, Magnetospheres in the Solar System
An overview of current knowledge and future research directions in magnetospheric physics In the six decades since the term 'magnetosphere' was first introduced, much has been theorized and discovered about the magnetized space surrounding each of the bodies in our solar system. Each magnetosphere is unique yet behaves according to universal physical processes. Magnetospheres in the Solar System brings together contributions from experimentalists, theoreticians, and numerical modelers to present an overview of diverse magnetospheres, from the mini-magnetospheres of Mercury to the giant planetary magnetospheres of Jupiter and Saturn. Volume highlights include: Concise history of magnetosphere...
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