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Beyond Mechanism
It has been said that new discoveries and developments in the human, social, and natural sciences hang “in the air” (Bowler, 1983; 2008) prior to their consummation. While neo-Darwinist biology has been powerfully served by its mechanistic metaphysic and a reductionist methodology in which living organisms are considered machines, many of the chapters in this volume place this paradigm into question. Pairing scientists and philosophers together, this volume explores what might be termed “the New Frontiers” of biology, namely contemporary areas of research that appear to call an updating, a supplementation, or a relaxation of some of the main tenets of the Modern Synthesis. Such areas...
Environmental Epigenomics in Health and Disease
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be ma...
Modifications of Nuclear DNA and Its Regulatory Proteins
DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Brain Development in Drosophila melanogaster
The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
A Companion to the Philosophy of Biology
A COMPANION TO THE PHILOSOPHY OF BIOLOGY “Sarkar is to be congratulated for assembling this talented team of philosophers, who are themselves to be congratulated for writing these interesting essays on so many fascinating areas in philosophy of biology. This book will be a wonderful resource for future work.” Elliot Sober, University of Wisconsin-Madison “Many of the discussions here start with a definition of terms and a historical context of the subject before delving into the deeper philosophical issues, making it a useful reference for students of biology as well as philosophy.” Northeastern Naturalist “The topics that are addressed are done so well. This book will appeal to th...
Innovative Endocrinology of Cancer
This volume is devoted to new developments in a huge range of topics, such as the mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and antihormonal therapy of cancer and its prevention.
Bacterial Signal Transduction: Networks and Drug Targets
This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.
Hot Topics in Infection and Immunity in Children V
Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections. This conference is being supported by several societies and is sponsored by several pharmaceutical companies, such as Aventis, Baxter, Chiron Vaccines, Wyeth, etc.
Transgenesis and the Management of Vector-Borne Disease
Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irr...
Idealization and the Aims of Science
Introduction : doing science in a complex world. Science by humans ; Science in a complex world ; The payoff : idealizations and many aims -- Complex causality and simplified representation. Causal patterns in the face of complexity ; Causal patterns ; Causal complexity ; Simplification by idealization ; Reasons to idealize ; Idealizations' representational role ; Rampant and unchecked idealization -- The diversity of scientific projects. Broad patterns : modeling cooperation ; A specific phenomenon : variation in human aggression ; Predictions and idealizations in the physical sciences ; Surveying the diversity -- Science isn't after the truth. The aims of science ; Understanding as science...
