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Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways
This book gathers some of the most talented and well-informed experts in the field, who not only summarize the recent breakthroughs and new findings, but also shed light on future research. Special emphasis is placed on the exciting new understanding of the molecular structure of one of the major enzymes (type 1 iodothyronine deiodinase) involved in the activation of the thyroid hormone. This breakthrough culminates the major effort in this field around the world. As a result, we can study the regulation of thyroid hormone activation mechanism at the molecular level. Two other important deiodinase enzymes (types II and III) are also reviewed. Alternate pathways of thyroid hormone metabolism represent another major advance. These pathways are associated with a variety of physiological and disease states, including fasting, glucocorticoid excess, fetal development, and inflammatory and non-thyroidal illnesses. The understanding of these pathways assists us to better understand the physiological and biological basis of the disease process and thus to improve clinical management of patients with thyroidal and non-thyroidal illnesses.
Homeless Narratives & Pretreatment Pathways
On any given night, there are over 643,000 homeless peopleresiding in shelters and on the streets across America. What can we do to help? "Levy crafts stories of characters who sear the memory: OldMan Ray, the World War II veteran who resents the VA system andregards himself as the de facto night watchman at Port Authority;Ben who claims to be a prophet disowned in his own country, crucifiedby the government and enslaved by poverty finds a bridge tothe mainstream services and a path to housing through the commonlanguage of religious metaphors, including redemption andforgiveness; and Andrew who has been 'mentally murdered' ishelped to understand his own situation and gain disability benefits...
A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
Stem Cells and Signaling Pathways
Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19. Interestingly, the clinical trials in the patients having COVID-19 compl...
Reprogramming Microbial Metabolic Pathways
Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.
Bioengineering and Molecular Biology of Plant Pathways
Approx.504 pagesApprox.504 pages
Skin Stress Response Pathways
It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cel...
Critical Pathways
Provides 753 citations from journals, bks., bk. chapters, conf. papers, meet. abstracts, dissert., theses, and Av's in all languages related to clinical pathways, care or clinical maps, clinical trajectories, and integrated plans of care. Contents: managed care, patient and staff educ., rural health, legal issues, informatics, variance tracking, and evaluation. Includes care for: ambulatory, cardiovascular, wound, geriatric, home health, infectious disease, long term, neurological, oncological, ophthalmological, pediatric, respiratory, renal, and women's health.
