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A Multidisciplinary Approach to Myelin Diseases
The present book is based on the papers presented during an inter disciplinary meeting which was held in Rome October 27-30, 1986, at the Istituto Superiore di Sanita under the sponsorship of NATO, and with a financial contribution of the Cassa di Risparmio di Roma. The meeting was of great interest because, for the first time, a group of highly qualified scientists specializing in different fields were gathered together to discuss the problem of demyelinating diseases. In thi. context molecular biologists, immunologists, virologists, and lipid chemists could discuss with clinicians for four days every aspect of demyelinating diseases. They shared results of the more recent research with the...
Opportunities and Challenges of the Therapies Targeting CNS Regeneration
The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.
Immunology of Nervous System Infections
This work brings together a variety of specialists from neurology, immunology, virology and the veterinary sciences, in an attempt to answer the questions raised. The relationship between infection and immunology in the nervous system is discussed fully. The work will appeal to clinicians and laboratory workers who wish to know more of this rapidly developing area, and will be of use to both established investigators and newcomers to the field.
Phonon Scattering in Condensed Matter
The Third International Conference on Phonon Scattering in Condensed Matter was held at Brown University, Providence, Rhode Island from August 28-31, 1979. The previous conferences in this series were held at Nottingham in 1975, and in France at Paris and Ste Maxime in 1972. Until about 15 years ago phonon scattering was studied almost exclusively by measurements of thermal conductivity. This approach has the severe limitation that the result obtained for the phonon scattering rate is actually the average of the scattering for all of the phonons in the sample. Thus, no distinction can be made between phonons of different polarization, direction of propagation, or energy. During the 1960's se...
Neuroimmunological Diseases
This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
From Basic Immunology to Immune-Mediated Demyelination
This book covers the immunological and clinical aspects of central and peripheral nervous system inflammatory diseases characterized by myelin damage. Leading scientists in the field have summarized in short reviews the state of the art of neuroimmunology, with particular emphasis on basic aspects of the regulation of immune responses during demyelinating disorders. The volume will be helpful to neuroimmunologists, but also to clinicians which will find a clear and concise understanding of the main features of neuroinflammatory disease.
Advances in Immunology
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Advances in Multiple Sclerosis Research—Series I
Designing immunotherapeutics, drugs, and anti-inflammatory reagents has been at the forefront of autoimmune research, in particular multiple sclerosis, for over 20 years. Delivery methods that are used to modulate effective and long-lasting immune responses have been the major focus. This Special Issue focused on delivery methods to be used for vaccines, immunotherapeutic approaches, drug design, and anti-inflammatories and their outcomes in preclinical studies and clinical trials.
Advances in Research on Neurodegeneration
Volume 5 of the series "Advances in Research on Neurodegeneration" is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and che...
