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Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
Handbook of Neurochemistry
This volume is concerned with the enzymes of the nervous system. Cerebral enzymes form the basis of the functional brain. They are needed for the control of the energetics of the nervous system, whether it be their release or their direction; for the elaboration of transmitters and for their destruction; for the synthesis, transport, and breakdown of all metabolites of the nervous system. They are indispensable for the control of the multitude of factors that govern our thinking and our behavior. They make it possible for us to comprehend what is taking place around us and perhaps to understand what may be in store for us. Enzymes are the stuff of life, and no living cell can be without them...
Neurodegenerative Diseases and Metal Ions
About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g.,...
Pathological Neurochemistry
More than for any other volume of the Handbook of Neurochemistry, the chap ters in this volume on Pathological Neurochemistry deal with the interface of the laboratory bench with the patient's bedside. Most of the chapters reflect the confluence of basic scientists, clinical investigators, and physicians. Con sidered here are many of the more important disorders that afflict the nerves, muscles, spinal cord, and/or brain of mankind throughout the world. There are well over 500 such disorders. And our understanding of their nature and of measures for effective prevention or treatment depends significantly on appli cation of the biochemical disciplines that characterize neurochemistry. Before ...
Alzheimer’s and Parkinson’s Diseases
This book is the outcome of an international conference, held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. This was the 30th in a series of the annual OHOLO Conferences, sponsored by the Israel Institute for Biological Research. Participants in this Conference consisted of scientists from four teen countries; represented a broad spectrum of research interests; and included a well-balanced representation from academia, clinical institutions and pharmaceutical industry. The book includes talks, poster sessions, and a comprehensive general discussion, all from the proceedings of this conference. In the interest of assuring a rapid publication of the novel infor mation revi...
Parkinson's Disease
Parkinson’s disease is a progressive neurodegenerative disorder charact- ized clinically by tremor, rigidity, slow movements, and postural instability. Pathologically, dopaminergic neurons of the substantia nigra bear the brunt of the degeneration, though other neuronal groups can be affected as well. Although Parkinson’s disease is the only neurodegenerative disorder for which effective therapies are available, these treatment options are only symptomatic, do not influence the underlying degenerative process, and are associated with a high incidence of complications, particularly with their long-term use. The progressive nature of the disease and the limitations of its palliative therap...
Noradrenergic Neurons
The Noradrenergic Neurons examines the mechanisms that regulate the release and synthesis of the neurotransmitter noradrenaline. Noradrenaline (or norepinephrine) and the physiological activity of the cells that manufacture and release it, play an important role in response to stress and the development of resistance to stress, as well as psychological mood itself. This book discusses the response of the various nonadrenergic receptor subtypes to noradrenaline, and the long-lasting changes that underlie the striking plasticity of function manifested by noradrenergic cells, which in turn are reflected in observable behavioral plasticity In recent years there has been no single book that presents an up-to-date synthesis of current knowledge on the biochemical, anatomical, and physiological aspects of this important group of brain and peripheral nervous system cells and their function in the whole behaving organism, and this book aims to fill that gap. This is informative reading for students of physiological psychology, neurochemistry, and medicine.
Preclinical Psychopharmacology
Psychopharmacology, Volume 2: Preclinical Psychopharmacology presents the mechanism of action of antidepressant drugs and neuroleptics. This book discusses the significance of the interaction between various neurotransmitter system in both biochemical and functional consequences of repeated drug administration. Organized into 12 chapters, this volume begins with an overview of the effects of antidepressant drugs on norepinephrine metabolism. This text then discusses the different aspects of monoamine oxidase and its inhibitors. Other chapters consider the mechanism of action of lithium, which requires consideration of some of the general characteristics of periodic behavior. This book discusses as well the preclinical aspects of tranquilizers, particularly those dealing with benzodiazepines and non-benzodiazepines acting through the benzodiazepine receptor. The final chapter deals with the various behavioral and electrophysiological effects of cocaine in animals, which presumably reflect both local anesthetic properties and action on monoamine mechanisms. This book is a valuable resource for neuropharmacologists and practicing psychiatrists.
Catecholamines I
Catecholamines are important transmitter substances in the autonomic and central nervous systems. These two volumes provide a comprehensive presentation of the state-of-the-art of catecholamine research and development in the past 15 years. The volumes present in-depth reviews of topical areas of catecholamine research in which substantial progress has been made and which are of current interest to various theoretical and clinical disciplines. Each topic has been dealt with by an established expert. Clinical subjects of relevant importance are included. Catecholamines are of interest in pharmacology, physiology, biochemistry, as well as in neurology, psychiatry, internal medicine (cardiology, hypertension, asthma), ophthalmology and anesthesiology.
Handbook of Neurotoxicity
This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of e...
