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Motor Neurons
Motor neuron diseases (MNDs) are a group of progressive neurodegenerative disorders associated with the degradation of the upper (UMN) or lower motor neurons (LMN) or both. They encompass amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), spinobulbar muscular atrophy (SBMA), hereditary spastic paraparesis (HSP), and others. MND patients present with a wide variety of clinical symptoms, including muscular weakness, atrophy, and corticospinal tract signs in diverse combinations. Over recent years, considerable collaborative efforts have been made to unravel the underlying pathophysiology of MNDs and find novel therapeutic interventions. With this book, we aim to provide both professionals and the general public with an outline of the latest scientific advances regarding the genetics, pathophysiology, diagnostics, and treatment options for MNDs. Researchers from different parts of the world have contributed to this volume in order to create a comprehensive multidisciplinary overview of the topics.
The Offline Dating Method
"The modern dating process is a mess - but it hasn't changed your innate desire for love and human connection. So rather than add to the exhausting narrative about the perils of digital dating, author Camille Virginia created a refreshing and powerful solution for it."--Amazon.
The Neurobiology and Genetics of Gilles de la Tourette Syndrome: New Avenues Through Large-Scale Collaborative Projects
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as hist...
Jews
An introduction to Jewish beliefs and practices, demonstrating that Judaism is a living religion which retains the vitality found in the Biblical corpus, but which has gone on to develop institutions, modes of behaviour and ideas which constitute the singularity of Jewish expression.
The Shtetl
"There is no possibility of entering the world of Yiddish, its literature and culture, without understanding what the shtetl was, how it functioned, and what tensions charged its existence. Whether idealized or denigrated, evaluated as the site of memory or mined for historical data, scrutinized as a socio-economic phenomenon or explored as the mythopoetics of a rich literature, the shtetl was the heart of Eastern European Jewry. The papers published in this volume - most of them presented at the second Mendel Friedman International Conference on Yiddish organized by the Oxford European Humanities Research Centre and the Oxford Institute for Yiddish Studies (July 1999) - re-examines the structure, organization and function of numerous small market towns that shaped the world of Yiddish. The different perspectives from which these studies view the shtetl trenchently re-evaluate common preconceptions, misconceptions and assumptions, and offer new insights that are challenging as they are informative."
The Fragile Ordinary
From the New York Times bestselling author of The Impossible Vastness of Us and the On Dublin Street series comes a heartfelt and beautiful new young adult fiction novel, set in Scotland, about daring to dream and embracing who you are.
Aging in the Social Space
A publication called Aging in the Social Space is a compilation of studies, which deal with theoretical understanding and empirical solutions, learning about problem spheres, specifying content parallels of social, legal, economic, moral and ethical views on senior issues in society, which are closely related to each other and are interconnected. This publication focus on the case study of Poland. It is supposed to provide a multidimensional view of old age issues and issues related to aging and care for old people in society. We believe that it is natural also to name individual spheres, in which society has some eff ect, either direct or indirect, within issues concerning seniors. Learning about these spheres is the primary prerequisite for successful use of social help to seniors in society.
Cannabis as Medicine
For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century, but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed, but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids, terpenoids and flavonoids found in Cannabis sativa L. These p...
Penguin Readers Level 4: Me Before You (ELT Graded Reader)
Penguin Readers is an ELT graded reader series. Please note that the eBook edition does NOT include access to the audio edition and digital book. Written for learners of English as a foreign language, each title includes carefully adapted text, new illustrations and language learning exercises. Titles include popular classics, exciting contemporary fiction, and thought-provoking non-fiction, introducing language learners to bestselling authors and compelling content. The eight levels of Penguin Readers follow the Common European Framework of Reference for language learning (CEFR). Exercises at the back of each Reader help language learners to practise grammar, vocabulary, and key exam skills...
Poor Europe
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