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Towards individualised treatment of tuberculosis
Each year, around 10 million of individuals develop active tuberculosis (TB). Worldwide, TB is the leading cause of death from an infectious agent surpassing both malaria and HIV. Current treatment regimens are long and therefore encompass a risk of nonadherence and development of acquired drug-resistance, reflected in the increase of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. Indeed, this calls for prudent use of existing TB drugs and improvement of TB treatment strategies. The aim of this thesis was to investigate the current drug susceptibility testing (DST) breakpoints for Mycobacterium tuberculosis (M. tuberculosis), the pharmacokinetics and pharmacodynamics (PK/...
Pharmacology of Infectious Diseases: World Tuberculosis Day 2022
World Tuberculosis (TB) Day takes place on 24th March and is designed to build awareness about the global epidemic of TB as well as the efforts and advances in eliminating the disease. TB is one of the leading causes of death from infectious diseases. The 24th March commemorates that day when Dr. Robert Koch announced that a small group of scientists at the University of Berlin’s Institute had discovered the cause of tuberculosis, the TB bacillus in 1882. This marked a turning point in the story of virulent human infectious diseases. It is in this spirit that Frontiers is launching this Research Topic to coincide with this United Nations (UN) day. This occasion not only offers an opportunity to acknowledge and build awareness of the diseases but also to consider the importance of research in pharmacology and advances in treatment strategies.
Essential Tuberculosis
This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.
Thoracic Ultrasound
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Coronavirus Politics
Global experts develop explanations of how governments responded to COVID-19
Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis
This 2011 update of Guidelines for the programmatic management of drug-resistant tuberculosis is intended as a tool for use by public health professionals working in response to the Sixty-second World Health Assembly's resolution on prevention and control of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Resolution WHA62.15, adopted in 2009, calls on Member States to develop a comprehensive framework for the management and care of patients with drug-resistant TB. The recommendations contained in these guidelines address the most topical questions concerning the programmatic management of drug-resistant TB: case-finding, multidrug resistance, treatment regimens, monitoring the response to treatment, and selecting models of care. The guidelines primarily target staff and medical practitioners working in TB treatment and control, and partners and organizations providing technical and financial support for care of drug-resistant TB in settings where resources are limited.
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of ...
Democracy in Times of Pandemic
Examines the most important democratic challenges of today, using the Covid-19 pandemic as a case study.
Basic Emergency Care: Approach to the Acutely Ill and Injured
Developed by WHO and the International Committee of the Red Cross, in collaboration with the International Federation for Emergency Medicine, "Basic Emergency Care (BEC): Approach to the acutely ill and injured" is an open-access training course for frontline healthcare providers who manage acute illness and injury with limited resources.BEC teaches a systematic approach to the initial assessment and management of time-sensitive conditions where early intervention saves lives. It includes modules on: the ABCDE and SAMPLE history approach, trauma, difficulty in breathing, shock, and altered mental status. The practical skills section covers the essential time-sensitive interventions for these key acute presentations.The BEC package includes a Participant Workbook and electronic slide decks for each module. BEC integrates the guidance from WHO Emergency Triage, Assessment and Treatment (ETAT) for children, WHO Pocket Book of Hospital Care for Children, WHO Integrated Management of Pregnancy and Childbirth and the Integrated Management of Adult/Adolescent Illness (IMAI).
Clinical Pharmacokinetics
Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.
