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Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of ...
Quantitative Pharmacology
PKPD awareness is vital if we are to attempt to relate preclinical results to the acute and long term consequences in humans. The debate on whether preclinical findings can be translated to the human usage is still engaging scientists across industry, academia and regulatory bodies. Pharmacokinetics (PK) and pharmacodynamics (PD) comprise traditionally distinct disciplines within pharmacology, the study of the interaction of drugs with the body. It is our intention to show that by deliberately, intimately and systematically integrate these disciplines our understanding of drugs and the efficiency and effectiveness of drug discovery and development may be greatly enhanced. The book is therefo...
Pharmacokinetics of Drugs
A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.
On the Left in America
Previously available only in an out-of-print Swedish edition published in 1955, Henry Bengston's firsthand account deals with what historian Dag Blanck calls the "other Swedish America." Swedish immigrants in general were conservative, but Bengston and others--most notably Joe Hill--joined the working-class labor movement on the left, primarily as Debsian socialists, although their ranks included other socialists, communists, and anarchists. Involved in the radical labor movement on many fronts, Bengston was the editor of Svenska Socialisten from 1912 until he dropped out of the Scandinavian Socialist Federation in 1920. Even after 1920, however, his sympathies remained with the movement he had once strongly espoused.
The forgotten history and the forgotten chronicle
I have taken up the old chronicles and the history of Sweden's oldest family, how members of this family were involved in shaping Sweden's history, one of the most famous Fale helped Erik Knutsson to the king's throne and is probably the same person as the fictional Arn, This Fale had decisive role together with Sune Folkesson in the battle of Gestilren and Lena.
Blood-Brain Barrier in Drug Discovery
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Principles and Practice of Pharmaceutical Medicine
The long awaited second edition of Principles and Practice of Pharmaceutical Medicine provides an invaluable guide to all areas of drug development and medical aspects of marketing. The title has been extensively revised and expanded to include the latest regulatory and scientific developments. New chapters include: European Regulations Ethics of Pharmaceutical Medicine Licensing and Due Diligence Pharmacogenomics Encompassing the entire spectrum of pharmaceutical medicine, it is the most up-to-date international guide currently available. Review of the first edition: “This book was a joy to read and a joy to review. All pharmaceutical physicians should have a copy on their bookshelves, all pharmaceutical companies should have copies in their libraries.” —BRITISH ASSOCIATION OF PHARMACEUTICAL PHYSICIANS
Legal Literacy in Premodern European Societies
This book analyses the legal literacy, knowledge and skills of people in premodern and modernizing Europe. It examines how laymen belonging both to the common people and the elite acquired legal knowledge and skills, how they used these in advocacy and legal writing and how legal literacy became an avenue for social mobility. Taking a comparative approach, contributors consider the historical contexts of England, Finland, France, Germany, Italy and Sweden. This book is divided into two main parts. The first part discusses various groups of legal literates (scriveners, court of appeal judges and advocates) and their different paths to legal literacy from the Middle Ages to the nineteenth century. The second part analyses the rise of the ownership and production of legal literature – especially legal books meant for laymen – as means for acquiring a degree of legal literacy from the eighteenth to the early twentieth century.
Early Drug Development, 2 Volume Set
This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.
Statistical Methods in Epilepsy
Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike. Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis,...
