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Implementing the New Biology
As the second decade of the 21st century begins, the challenge of how to feed a growing world population and provide sustainable, affordable energy to fulfill daily needs, while also improving human health and protecting the environment, is clear and urgent. Increasing demand for food and energy is projected at the same time as the supply of land and other resources decrease. Increasing levels of greenhouse gasses alter climate, which, in turn, has life-changing implications for a broad range of plant and animal species. But promising developments are on the horizon-scientific discoveries and technologies that have the potential to contribute practical solutions to these seemingly intractabl...
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Biochemical Actions of Hormones V5
Biochemical Actions of Hormones, Volume V explores the nature of interaction of multiple hormones in regulating specific phenotypes. This volume is organized into 11 chapters that include discussions on the developments in the understanding of the biochemistry and molecular biology of hormones. The opening chapters deal with the modifications of chromatin structure by hormones, the regulation of exocytosis, ontogeny of estrogen receptors, and the hormonal regulation of cells of the seminiferous tubule. The discussions then shift to the advances on the progesterone receptor, the role of glucocorticoids in the integration of mammary tumor virus genes, and a model system for estrogen action. Other chapters examine the physiology, molecular action, and biological effects of somatomedins, epidermal growth factors and 1,25-dihydroxyvitamin. The remaining chapters focus on multihormone control of mRNA for a specific hepatic protein. This book is of great value to endocrinologists.
Big Pharma
To many Americans, the term big pharma evokes thoughts of greedy organizations that put profits ahead of people's health. It's difficult to put a price tag on drugs that improve or save lives. It's even harder to stomach the thought of being unable to afford medicines when we may need them most. With the price of pills reaching an all-time high, we are looking for justifications and turning to our government for solutions. The articles in this collection provide valuable coverage and insights into the practices of drug manufacturers, the driving forces behind the costs we face today, and what, if anything, can be done to satiate the hunger of big pharma. Media literacy questions and terms will engage readers beyond the text and aid them in considering the many facets of this complicated issue.
Glucocorticoid Signaling
This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Meeting Critical Laboratory Needs for Animal Agriculture
Outbreaks of animal disease can have catastrophic repercussions for animal agriculture, the food supply, and public health. Rapid detection, diagnosis and response, as well as development of new vaccines, are central to mitigating the impact of disease outbreaks. The proposed National Bio- and Agro-Defense Facility (NBAF) is a next-generation laboratory for animal disease diagnostics, training, and research that would provide core critical components for defense against foreign animal and zoonotic disease threats. But it will be a major investment with estimated construction costs of $1.14 billion, as currently designed. Meeting Critical Laboratory Needs for Animal Agriculture: Examination of Three Optionsdiscusses the laboratory infrastructure needed to effectively address the threat posed by animal and zoonotic diseases and analyzes three options for creating this infrastructure: building NBAF as currently designed, building a scaled-back version of the NBAF, or maintaining current research capabilities at Plum Island Animal Disease Center while leveraging biosafety level-4 large animal capabilities at foreign laboratories.
Inside the CIA
Ronald Kessler’s explosive bestseller, The FBI, brought down FBI Director William S. Sessions. Now, in this unparalleled work of investigative journalism, Kessler reveals the inner world of the CIA. Based on extensive research and hundreds of interviews, including several with former Directors of Central Intelligence, Inside the CIA is the first in-depth, unbiased account of the Agency’s core operations, its abject failures, and its resounding successes. Kessler reveals how: -CIA analysts botched the job of foreseeing the Soviet economy’s collapse -The Agency spies on every country in the world except Great Britain, Australia, and Canada -The CIA undertakes covert action to influence or overthrow foreign governments or political parties -The Agency trains its officers to break the laws of other countries Inside the CIA is an extraordinary guide to the world’s most successful house of spies.
