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During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxida...
Designed to synthesize the collective wisdom of a tumor board, the book presents a multidisciplinary, evidence-based approach to the contemporary management of head and neck cancer. Expert authors and contributors provide a balanced literature review that provides the reader with a solid understanding of the fundamental concepts of the disease entity, descriptions of anatomy, physiology, and clinical presentation, discussion of diagnostic workup and the various management techniques.Highlights: Each chapter features the clinical insights of a surgeon, a medical oncologist, and a radiation oncologist Comprehensive coverage of the most important disease sites, including the oral cavity, oropha...
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial phys...
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" ... A compilation of 122 taxa of butterflies and moths that are of special interest in the Pacific Northwest, regarding forest service management and conservation. ... The list of butterflies and moths is dominated by species and subspecies that are uncommon or rare, but we have included species that are widely distributed and associated with particular plant communities of special interest in the Pacific Northwest ..."--Taken from p. ii, About This Book.
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Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
Presents the technical aspects of IMRT, and the clinical aspects of planning and delivery. The volulme explores a practical approach for radiation oncologists and medical physicists initiating or expanding and IMRT program, the fundamental biology and physics of IMRT, a site-by-site review of IMRT techniques with clinical examples, and reviews of published outcome studies.