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I Deserted Rommel
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Degenerate Art
Looks at the reconstructed exhibit of degenerate art censored by the Nazis in 1937
Ethnic Fermented Foods and Beverages of India: Science History and Culture
This book provides detailed information on the various ethnic fermented foods and beverages of India. India is home to a diverse food culture comprising fermented and non-fermented ethnic foods and alcoholic beverages. More than 350 different types of familiar, less-familiar and rare ethnic fermented foods and alcoholic beverages are traditionally prepared by the country’s diverse ethnic groups, and include alcoholic, milk, vegetable, bamboo, legume, meat, fish, and cereal based beverages. Most of the Indian ethnic fermented foods are naturally fermented, whereas the majority of the alcoholic beverages have been prepared using dry starter culture and the ‘back-sloping’ method for the p...
Knowledge Engineering and Knowledge Management. Methods, Models, and Tools
This book constitutes the refereed proceedings of the 12th International Conference on Knowledge Engineering and Knowledge Management, EKAW 2000, held in Juan-les-Pins, France in October 2000. The 28 revised full papers and six revised short papers presented were carefully reviewed and selected from a high number of high-quality submissions. The book offers topical sections on knowledge modeling languages and tools, ontologies, knowledge acquisition from texts, machine learning, knowledge management and electronic commerce, problem solving methods, knowledge representation, validation, evaluation and certification, and methodologies.
Carbonic Anhydrase as Drug Target
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
Applications of Fuzzy Sets Theory
The 7th International Workshop on Fuzzy Logic and Applications, held in Camogli, Italy in July 2007, presented the latest findings in the field. This volume features the refereed proceedings from that meeting. It includes 84 full papers as well as three keynote speeches. The papers are organized into topical sections covering fuzzy set theory, fuzzy information access and retrieval, fuzzy machine learning, and fuzzy architectures and systems.
Protein-Ligand Interactions and Drug Design
This detailed book collects modern and established computer-based methods aimed at addressing the drug discovery challenge from disparate perspectives by exploiting information on ligand-protein recognition. Beginning with methods that allow for the exploration of specific areas of chemical space and the designing of virtual libraries, the volume continues with sections on methods based on docking, quantitative models, and molecular dynamics simulations, which are employed for ligand discovery or development, as well as methods exploiting an ensemble of protein structures for the identification of potential protein targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein-Ligand Interactions and Drug Design provides detailed practical procedures of solid computer-aided drug design methodologies employed to rationalize and optimize protein-ligand interactions, for experienced researchers and novices alike.
