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Brain function is under metabolic control, which in turn determines the equilibrium of homeostatic systems that affect neuronal and glial networks on the molecular, cellular, and systems levels. The collection of articles ranges from molecules and mechanisms involved in regulating homeostasis and neuronal excitability to therapeutic mechanisms tailored to restore homeostatic function. It also features neurological diseases and novel treatment approaches that are based on metabolic and homeostatic interventions. Together, the collection of articles outlines novel strategies to restore brain function in neurology and highlights limitations of conventional pharmacological approaches. We suggest that restoration of molecular and biochemical networks could lead to a new era of therapeutic opportunities.
**WINNER OF THE WELLCOME BOOK PRIZE 2014** A NEW YORK TIMES BESTSELLER Sometimes your child - the most familiar person of all - is radically different from you. The saying goes that the apple doesn't fall far from the tree. But what happens when it does? Drawing on interviews with over three hundred families, covering subjects including deafness, dwarfs, Down's Syndrome, Autism, Schizophrenia, disability, prodigies, children born of rape, children convicted of crime and transgender people, Andrew Solomon documents ordinary people making courageous choices. Difference is potentially isolating, but Far from the Tree celebrates repeated triumphs of human love and compassion to show that the shared experience of difference is what unites us. Winner of the National Book Critics Circle Award for General Non-fiction and eleven other national awards. Winner of the Green Carnation Prize.
Abraham Kurtz was born about 1720 in Germany and died 1782 in Earl Township, Lancaster County, Pennsylvania. He emigrated to America in 1749 (possibly 1740). Abraham married three times: Margaret Bollinger, Barbara Bollinger, and Catharine (last name unknown).
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