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Comorbidities in Developmental Disorders
Clinics in Developmental Medicine No. 187 In the last decade the term ‘comorbidity’ has gained popularity in the field of paediatric neurodisability, with the increasing recognition that many conditions are rarely present in isolation. Within this field, the term is often used to refer to the co-occurrence of conditions more frequently than would be expected by chance, which can include instances where one condition causes the other, where they share a common cause (for example, genetic), or where they are in fact manifestations of a single condition. Whether it is valid to use the term ‘comorbidity’ in all these situations, and how precisely it should be used, is something that the ...
Towards Mechanism-based Treatments for Fragile X Syndrome
It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.
Securing the Future
More than ever, the economic health of a country depends upon the skills, knowledge, and capacities of its people. How does a person acquire these human assets and how can we promote their development? Securing the Future assembles an interdisciplinary team of scholars to investigate the full range of factors—pediatric, psychological, social, and economic—that bear on a child's development into a well-adjusted, economically productive member of society. A central purpose of the volume is to identify sound interventions that will boost human assets, particularly among the disadvantaged. The book provides a comprehensive evaluation of current initiatives and offers a wealth of new suggesti...
FXTAS, FXPOI, and Other Premutation Disorders
This book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS, FXPOI and their families, as well as presenting the molecular basis for disease that may lead to the identification of new markers to predict disease risk and eventually lead to target treatments. The book will present information on all aspects of FXTAS, FXPOI and other premutation disorders including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed.
Pediatric Neuropsychology
Recognized as the definitive reference and text on the relationship between brain health and behavior in children and adolescents, this volume is now in a third edition with 75% new material, including major updates throughout and numerous new chapters. Leading experts provide a neuropsychological perspective on medical, neurological, genetic, and developmental disorders that are frequently seen in clinical practice. The volume examines the impact of each condition on the developing brain; explores associated cognitive, behavioral, and psychosocial impairments; and shows how the science translates into achieving better outcomes for children. New to This Edition *Reflects 12 years of signific...
International Bibliography Of Sociology 2003/Bibliographie Internationale Des Sciences Sociales
First published in 1952, the International Bibliography of the Social Sciences (anthropology, economics, political science, and sociology) is well established as a major bibliographic reference for students, researchers and librarians in the social sciences worldwide. Key features * authority: Rigorous standards are applied to make the IBSS the most authoritative selective bibliography ever produced. Articles and books are selected on merit by some of the world's most expert librarians and academics. * breadth: today the IBSS covers over 2000 journals - more than any other comparable resource. The latest monograph publications are also included. * international Coverage: the IBSS reviews scholarship published in over 30 languages, including publications from Eastern Europe and the developing world. *User friendly organization: all non-English titles are word sections. Extensive author, subject and place name indexes are provided in both English and French.
Autism and Other Neurodevelopmental Disorders
Autism and Other Neurodevelopmental Disorders gathers and organizes the most recent information in this important and rapidly expanding field into a clinically useful volume that will enable clinicians, patients, and families to understand these disorders and make sound treatment decisions in light of recent research. The editors, as well as most of the chapter authors, are faculty or former trainees at the prestigious Medical Investigation of Neurodevelopmental Disorders (MIND) Institute at UC-Davis, a collaborative international research center committed to the awareness, understanding, prevention, care, and cure of neurodevelopmental disorders, including autism spectrum disorders, ADHD, learning disorders, and more. Each chapter presents signs and symptoms; epidemiology and etiology; diagnostic approaches; evidence based interventions; and reviews of promising research. By focusing on the range of neurodevelopmental disorders commonly seen and managed by both primary and subspecialist health care professionals. Autism and Other Neurodevelopmental Disorders explains cutting-edge research and advances in clinical care, and assembles them into a single, indispensable volume.
Sorrow's Web
Drawing on her experience of growing up with a depressed mother and then, years later, of becoming a depressed mother herself, Books for a Better Life winner Anne Sheffield casts long-overdue light on the grave threat to the health and happiness of millions of women and their children posed by maternal depression. One of every four women suffers from depression at some point in her life, often during the prime childbearing years, yet most fail to recognize the true source of their lack of joy in life and in parenting, their irritability and exhaustion, and the flawed personal relationships that characterize this common, treatable disease. With honesty and empathy, Sheffield uses her own stor...
