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Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or ...
This is the first book to present a roadmap for tailoring acceptance and commitment therapy (ACT) to the serious, complex challenges of anorexia nervosa (AN). Leading authorities describe interventions grounded in ACT core processes--Defusion, Acceptance, Attention to the Present Moment, Self-Awareness, Values, and Committed Action. Guidance is provided for conducting functional assessments with adolescents and adults and working toward individualized treatment goals, starting with weight restoration. The book also discusses ways to engage parents and other family members in treatment. It features therapist scripts, sample dialogues, case examples, and reproducible forms and handouts. The large-size format facilitates photocopying; purchasers also get access to a Web page where they can download and print the reproducible materials.
This work contains abstracts of the intestate records of the fifty-seven Georgia counties formed before the 1832 Land Lottery, plus those for Fulton (1853), White (1857), Dawson (1857), and Webster (1853) counties. Besides the name of the deceased and the dates of the various court papers, information in the abstracts includes the names of the administrators, sureties and guardians (often relatives of the deceased), names of the surviving spouse and children, the names of orphan children and heirs, and, where a will is recorded, the names of the legatees!