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Software Engineering and Knowledge Engineering
This volume focuses on current and future trends in the interplay between software engineering and artificial intelligence.This interplay is now critical to the success of both disciplines, and it also affects a wide range of subject areas. The articles in this volume survey the significant work that has been accomplished, describe the state of the art, analyze the current trends, and predict which future directions have the most potential for success. Areas covered include requirements engineering, real-time systems, reuse technology, development environments and meta-environments, process representations, safety-critical systems, and metrics and measures for processes and products.
Foundations of Intelligent Systems
This book constitutes the refereed proceedings of the 16th International Symposium on Methodologies for Intelligent Systems, ISMIS 2006. The book presents 81 revised papers together with 3 invited papers. Topical sections include active media human-computer interaction, computational intelligence, intelligent agent technology, intelligent information retrieval, intelligent information systems, knowledge representation and integration, knowledge discovery and data mining, logic for AI and logic programming, machine learning, text mining, and Web intelligence.
Learning and Intelligent Optimization
This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Conference on Learning and Intelligent Optimization, LION 5, held in Rome, Italy, in January 2011. The 32 revised regular and 3 revised short papers were carefully reviewed and selected from a total of 99 submissions. In addition to the contributions to the general track there are 11 full papers and 3 short papers presented at the following four special sessions; IMON: Intelligent Multiobjective OptimizatioN, LION-PP: Performance Prediction Self* EAs: Self-tuning, self-configuring and self-generating evolutionary algorithms LION-SWAP: Software and Applications.
Protein Allostery in Drug Discovery
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and ne...
Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with cla...
Evolutionary Computation in Combinatorial Optimization
This book constitutes the refereed proceedings of the 12th European Conference on Evolutionary Computation in Combinatorial Optimization, EvoCOP 2012, held in Málaga, Spain, in April 2012, colocated with the Evo* 2012 events EuroGP, EvoBIO, EvoMUSART, and EvoApplications. . The 22 revised full papers presented were carefully reviewed and selected from 48 submissions. The papers present the latest research and discuss current developments and applications in metaheuristics - a paradigm to effectively solve difficult combinatorial optimization problems appearing in various industrial, economic, and scientific domains. Prominent examples of metaheuristics are evolutionary algorithms, simulated annealing, tabu search, scatter search, memetic algorithms, variable neighborhood search, iterated local search, greedy randomized adaptive search procedures, estimation of distribution algorithms, and ant colony optimization.
Information Intelligence, Systems, Technology and Management
This book constitutes the refereed proceedings of the 5th International Conference on Information Systems, Technology and Management, ICISTM 2011, held in Gurgaon, India, in March 2011. The 35 revised full papers presented together with 4 short papers were carefully reviewed and selected from 106 submissions. The papers are organized in topical sections on information management, information systems, information technology, healthcare information management and technology, business intelligence, applications, as well as management science and education.
Numerical Methods and Applications
This book constitutes the thoroughly refereed post-proceedings of NMA 2006 held in Borovets, Bulgaria. Coverage in the 84 revised full papers includes numerical methods for hyperbolic problems, robust preconditioning solution methods, metaheuristics for optimization problems, uncertain/control systems and reliable numerics, interpolation and quadrature processes, and large-scale computations in environmental modeling.
