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Inflammatory Mechanisms in Mediating Hearing Loss
Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these fin...
Free Radicals in ENT Pathology
This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and “white paper” that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.
Delivering Therapeutics to the Inner Ear
Topic Editor Benjamin Shapiro is President and co-founder of Otomagnetics. Topic Editor Sylvain Celanire is a co-Founder and Chief Executive Officer of PRAGMA Therapeutics. All other Topic Editors declare no competing commercial interests with regards to the Research Topic subject.
The Nescience of Medicine
The Nescience of Medicine Includes - COVID-19 THE UN-TOLD STORY Part 2 Provides a Detailed Explanation of the Covid-19 Fraud An inside account of the events Before, During and After! CONTENTS Preface.........................................................................................1 Advice to the Medical Trade.......................................................2 We Have Been Here Before........................................................3 Chapter 1 Science and Nescience................................................................4 Covid-19 The UN-Told Story Part 2...........................................7 Dis-information Mis-information Mal-information & The Medical Trade.....
