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Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
In its 114th year, Billboard remains the world's premier weekly music publication and a diverse digital, events, brand, content and data licensing platform. Billboard publishes the most trusted charts and offers unrivaled reporting about the latest music, video, gaming, media, digital and mobile entertainment issues and trends.
An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.
Dr. Cloyd Ovid Trouth’s book, Times are Changing and the Struggle Continues, provides a unique perspective on his life. In addition, it gives a balanced viewpoint of some of the cultural and societal issues that have occurred and continue to plague the United States and the world. Among other issues, Dr. Trouth describes and analyzes, through his memoir, racial inequality, poverty, the long-lasting effects of slavery, and man’s inhumanity to man. He writes engagingly and with sharp wit about the problems that, for example, African-Americans in the United States still face. Everyone can learn something through Dr. Trouth’s story of his own life, which gives a complex historical viewpoint on the United States as well.