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Leading experts comprehensively review all aspects of the delivery of therapeutic molecules to cells using electrical impulses-i.e., the extraordinarily promising new areas of electrogenetherapy, electrochemotherapy, and transdermal drug delivery. Their survey ranges from outlines of the basic physical principles that govern cell permeabilization by pulsed electric fields, to descriptions of the current state-of-the-art in instrumentation and electrodes, to summaries of preclinical and clinical trial results. The authors focus on drug, gene, and transdermal delivery techniques, providing detailed examples of drug delivery using electric fields from a variety of pulse generators and electrodes. Comprehensive and authoritative, Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells provides entré to an immensely practical set of in vivo electroporation techniques, including electrogenetherapy, electrochemotherapy, and transdermal drug delivery-techniques holding great promise for all those working toward better therapies for cancer, metabolic diseases, and vaccination.
The Iron Curtain was seen as the divider between East and West in Cold War Europe. The term refers to a material reality but it is also a metaphor; a metaphor that has become so powerful that it tends to mark our historical understanding of the period. Through the archaeological study of two areas that can be considered part of the former Iron Curtain, the Czech-Austrian border and the Italian-Slovenian border, this research investigates the relationship between the material and the metaphor of the Iron Curtain. As a study of the archaeology of the contemporary past this thesis brings forward methodological issues when dealing with many different sources as well as general reflections on our historical understanding.
Elections, Parties and Representation in Post-Communist Europe 1990-2002 stresses the ways in which the development of political parties affected the quality of democracy, the nature of political representation, and political accountability in the early stages of post-communist politics. It also analyzes the nature and consequences of the corpus of parliamentary candidates and deputies for the representation of social classes, women and minorities. In contrast with the wide social profile of communist parliaments, politics largely became the playground of new highly educated male elites.
This theoretically and empirically grounded book uses case studies of political graffiti in the post-socialist Balkans and Central Europe to explore the use of graffiti as a subversive political media. Despite the increasing global digitisation, graffiti remains widespread and popular, providing with a few words or images a vivid visual indication of cultural conditions, social dynamics and power structures in a society, and provoking a variety of reactions. Using qualitative and quantitative methods, as well as detailed interdisciplinary analyses of "patriotic," extreme-right, soccer-fan, nostalgic, and chauvinist graffiti and street art, it looks at why and by whom graffiti is used as political media and to/against whom it is directed. The book theorises discussions of political graffiti and street art to show different methodological approaches from four perspectives: context, author, the work itself, and audience. It will be of interest to the growing body of literature focussing on (sub)cultural studies in the contemporary Balkans, transitology, visual cultural studies, art theory, anthropology, sociology, and studies of radical politics.
The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications....
This supplement comes not only to correct the inaccuracies and mistakes in the authors monograph of 1997, but also to update the nomenclature, taxonomy and distribution of the Alticinae, or flea beetles, in the Palaearctic subregion. As a result, 83 names of flea beetles are eliminated, mostly as synonyms, while 113 species are added. So the total number of species or subspecies has increased from 1,358 to 1,388. The following three genera are added to the regional list: Aeschrocnemis, Cyrsylus and Heyrovskya. Blagoi Gruev, born 1936, is a lecturer of general biogeography at the University of Plovdiv, the author of the first textbook on this subject in Bulgaria, who also provided an original biogeographical division of the country. He has described 64 new taxa of Chrysomelidae from various parts of the Palaearctic, Oriental and Afrotropical realms. Manfred Doberl, born 1933, has devoted 40 years of his life to teaching and entomology. He has also described numerous new Palaearctic and Oriental flea beetles, published in more than 30 papers.
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Ravnikar is considered the central figure in Slovenia's post-WWII architecture. This monograph contains documentation on his buildings and written work, 800 color illustrations, and contributions from Friedrich Kurrent, Boris Podrecca and many others.
In this finely wrought memoir of life in postcolonial Pakistan, Suleri intertwines the violent history of Pakistan's independence with her own most intimate memories—of her Welsh mother; of her Pakistani father, prominent political journalist Z.A. Suleri; of her tenacious grandmother Dadi and five siblings; and of her own passage to the West. "Nine autobiographical tales that move easily back and forth among Pakistan, Britain, and the United States. . . . She forays lightly into Pakistani history, and deeply into the history of her family and friends. . . . The Suleri women at home in Pakistan make this book sing."—Daniel Wolfe, New York Times Book Review "A jewel of insight and beauty. ...
While a cure for spinal cord injury remains elusive, the contents of this volume convey a sense of progress towards this goal. More has been learned about the primary and secondary consequences of spinal cord injury and more is being understood about recovery mechanisms that are intrinsic to the nervous system and that might be further encouraged. Expanding the control capacity of uninjured portions of the nervous system may be one approach to improving the functional capabilities of those afflicted with this disorder. New therapies in the form of transplantable cells that can encourage growth or myelination or prevent secondary damage or that can substitute for injured cells appear promisin...