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Keep Calm and Trust the Science
Professor Luke O'Neill has become one of the most well-known and trusted voices of Ireland's COVID-19 pandemic, thrust into the spotlight as we struggled to make sense of a crisis that saw the country grind to a halt. In these personal diaries, Luke reveals what life was like behind the scenes as he endeavoured to keep calm and trust that the science would save us. Luke's lockdown diaries show the highs and lows of work at the cutting edge in his Trinity College lab, as well as his experience of the disappointments and the breakthroughs in science around the world, and ultimately the contribution scientists made to the health outcomes of millions globally. Shot through with the natural positivity and humour that have made Luke a home-grown hero, Keep Calm and Trust the Science is a compelling account of a dramatic year in Irish history from one of its key players.
Never Mind the B#ll*cks, Here's the Science
In this fascinating and thought-provoking book, Ireland's favourite scientist Professor Luke O'Neill grapples with life's biggest questions and tells us what science has to say about them: DO WE HAVE CONTROL OVER OUR LIVES? CAN WE ESCAPE WORKING IN BULLSH*T JOBS? MUST WE VACCINATE? ARE MEN'S AND WOMEN'S BRAINS DIFFERENT? WILL WE DESTROY THE PLANET? As he covers topics such as global pandemics, addiction and euthanasia, Luke's trademark easy wit and clever pop-culture references deconstruct the science to make complex questions accessible. Arriving at science's definitive answers to some of the most controversial issues human beings have to contend with, Never Mind the B#ll*cks, Here's the Science is a celebration of science and hard facts in a time of fake news and sometimes unhelpful groupthink.
The Great Irish Science Book
Join Trinity's Professor Luke O'Neill on the greatest journey of them all. From the very big to the very small - vast galaxies to microscopic atoms - travel through the wonders of the universe, the mysteries of the human body, and the tiny world of molecules. Discover the Irish scientists that have helped to shape our world and find out how to become one yourself. How do we measure the universe? Why do we need plants? How do our bodies repair themselves when we are ill? What species will exist on earth in a million years' time? Discover the answers to these questions and a lot more in this thrilling and engrossing book packed with fascinating phenomena, vibrant illustrations, experiments you can do yourself, and heaps of fun facts.
What is Life? The Next Fifty Years
Erwin Schrödinger's book What is Life? had a tremendous influence on the development of molecular biology, stimulating scientists such as Watson and Crick to explore the physical basis of life. Much of the appeal of Schrödinger's book lay in its approach to the central problems in biology - heredity and how organisms use energy to maintain order - from a physicist's perspective. At Trinity College, Dublin a number of outstanding scientists from a range of disciplines gathered to celebrate the fiftieth anniversary of What is Life? and following Schrödinger's example fifty years previously, presented their views on the current central problems in biology. The contributors to this volume include Stephen Jay Gould, Roger Penrose, Jared Diamond, Manfred Eigen, John Maynard Smith, Christien de Duve and Lewis Wolpert. This collection is essential reading for anyone interested in biology and its future.
Human Airway Inflammation
Rubor (redness), tumor (swelling), calor (heat), and dolor (pain) are the classical signs of inflammation. These features are obvious in the skin, where injury or disease causes flare, wheal, and painful burning sensations. Vasodi- tation underlies the flare and heat, plasma exudation the swelling, and acti- tion of sensory nerves relays pain. In chronic conditions, skin biopsies show inflammatory cell infiltrate. Inflammation is not unique to the skin and contr- utes to disease and repair processes in other organ systems in the body. From the viewpoint of this volume, lung inflammation is now recognized as central to the pathophysiology of a number of severe respiratory conditions, the two ...
Molecular Analysis of Cancer
Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chap...
Encyclopedia of Molecular Pharmacology
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Haemophilus influenzae Protocols
In HaemophilusiInfluenzae Protocols, leading research scientists and infectious disease specialists detail in a readily reproducible format the major molecular and immunological techniques for exploring the pathogenicity of H. influenzae. Described with step-by-instructions to ensure robust and successful experimental results, the techniques cover plasmid analysis, proteomics, genomics, DNA array technology, gene expression, mutagenesis (transposon and nontransposon), and structural analysis. These methods illuminate how the bacterium causes disease, as well as how best to develop novel vaccines and antibiotics against the organism.
Innate Immune Regulation and Cancer Immunotherapy
Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Manufacturing the Bespoke
The essential reader on fabrication in architecture for practitioners and producers alike An original and informative reader on the subject of translating architectural ideas from conceptual propositions to physical manifestations, Manufacturing the Bespoke is an essential resource for students and practitioners of architecture, as well as producers and suppliers of architectural products. At a time where roles, methods and capabilities within the disciplines of building production are in unprecedented flux, this book: Provides a unique and highly current treatment on the subject of fabrication in architecture with its emphasis on contemporary technology, cultural history and theory A key so...
