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Endotoxin in Health and Disease
Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Brain Fever: How Vaccines Prevent Meningitis
"In Brain Fever, the internationally renowned medical scientist, Richard Moxon FRS, shares his experiences about bacterial meningitis, a fearful and devastating infection of the brain. In a clear, non-technical style, he explains what meningitis is, what causes it, who gets it and how research has come up with vaccines that can prevent it. A paediatrician, Moxon engages the reader in a compelling story of how chance, opportunity and passion drew him into researching the bacteria that are the lethal assassins of unsuspecting, previously healthy people, especially young children. The reader is taken on an exciting journey from his boyhood dream to study medicine to adventurous experiences as a...
Genomics, Proteomics, and Clinical Bacteriology
Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essen...
New Generation Vaccines
Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition, details steps developing countries have taken toward research, development, manufacture, and regulation of several new vaccines for widespread use. This text will: cover the current state-of-the-art techniques in vaccine development – including the successes and the failures trace vaccine development from the bench to public health with regard to both FDA and European Union regulations investigate improved methods fo...
Immunology of Human Infection
When we were first approached by the senior editors of this series to edit a book on interactions between the host and infectious agents, we accepted this offer as an exciting challenge. The only condition, readily agreed upon, was that such a book should focus on the immunology of infections in humans. Our reasons, if not biases, were severalfold. We sensed that the fields of microbiology and im munology, which had diverged as each was focusing on its individual search, were coming together. In agreement with the opinions expressed by Dr. Richard Krause in the Introduction, we strongly believed that the development of the immune system evolved in response to infectious agents and that the e...
Wound Healing
During the past decade, significant progress in molecular and cellular te- niques has greatly advanced our understanding of the wound healing p- cess. Many of these new techniques have been utilized in the context of more classic models of wound healing. The combination of new and classic approaches has allowed scientists to make exciting discoveries in the field of tissue repair, resulting in an explosion of information about the healing p- cess. Importantly, these new findings have great relevance beyond wound healing itself. The injury repair process cuts across many disciplines, exte- ing to such broad fields as cancer, inflammation, and atherosclerosis. The relevance of the field to the...
The Direct Detection of Microorganisms in Clinical Samples
The Direct Detection of Microorganisms in Clinical Samples focuses on the most practical and widely used procedures for direct detection of microorganism in clinical specimens. It considers application to virology, mycology, and bacteriology. Organized into three parts, the book begins with established techniques for visualization of intact organism in clinical samples. The book then deals with immunologic techniques for detecting soluble microbial antigens. The last part considers diverse non-immunologic methods for detecting soluble constituents of organisms and their metabolites. Clinical microbiologists, infectious disease clinicians and researchers, and individuals working in analogous areas will find this book invaluable.
Clinical Infectious Diseases
Noted in Annals of Pharmacotherapy
Blood'Brain Barrier
Blood–brain barrier (BBB) breakdown leading to cerebral edema occurs in many brain diseases—such as trauma, stroke, inflammation, infection, and tumors—and is an important factor in the mortality arising from these con- tions. Despite the importance of the BBB in the pathogenesis of these diseases, the molecular mechanisms occurring at the BBB are not completely und- stood. In the last decade a number of molecules have been identified not only in endothelial cells, but also in astrocytes, pericytes, and the perivascular cells that interact with endothelium to maintain cerebral homeostasis. However, the precise cellular interactions at a molecular level in steady states and d- eases hav...
