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Current Trends in the Identification and Development of Antimicrobial Agents
Despite an increase in life expectancy over the past 20 years, the number of novel, multidrug resistant microorganisms has also risen dramatically. To reduce the risk of reemerging infections, and limit the spread of multidrug resistant microorganisms, it is urgently necessary to develop safe and effective therapeutic countermeasures. New antimicrobial chemicals are mostly produced with the help of microorganisms, and the bulk of medications now on the market are of this type. The use of high therapeutic screening and recent developments in analytical instrumentation has allowed the researchers to identify novel antimicrobial compounds from bacteria, fungi, plants, mushrooms, algae, and othe...
Integrated Omics Approaches to Infectious Diseases
This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
Bioactive Natural products in Drug Discovery
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
The Marine Microbiome
This updated and expanded second edition reviews numerous aspects of the marine microbiome and its possible industrial applications. The marine microbiome is the total of microorganisms and viruses in the ocean and seas and in any connected environment, including the seafloor and marine animals and plants. In the first part of the book, diversity, origin and evolution of the marine microorganisms and viruses are discussed. The microbes presented originate from all three domains of life: Bacteria, Archaea, and Eukarya. The second part sheds some light on the different communities: it describes marine habitats and how their inhabitants control biogeochemical cycles. The third part finally examines the microbial ocean as a global system and evaluates methods of utilizing marine microbial resources. Adopting a translational approach, the book connects academic research with industrial applications, making it a fascinating read and valuable resource for microbiologists from both domains.
Melatonin: Role in Plant Signaling, Growth and Stress Tolerance
The new edited volume on phytomelatonin and its diverse roles in plants under a challenging environment shall be an important reference book with updated information and future perspectives on the involvement of this biomolecule in stress resilience in plants. Investigations on different aspects of melatonin in plants have undergone a prolific surge in the last decade. In view of such a considerable volume of investigations in melatonin, the proposed new volume will collate its role in different aspects of plants signaling, growth and metabolism. In this context, it has been important to understand its function as a stress priming molecule that executes associative synergistic relation with ...
Bio-Inspired Land Remediation
Land is fundamental to the human life. The upper layer of land is a non-renewable resource, and source of food. Therefore, land health is essential to long-term food security and to promote sustainable livelihoods. On account of urbanization, industrialization and population growth, land pollution is one of the major issues worldwide. As a result, land pollution is continuing across the world, and has been linked with a wide range of potentially toxic contaminants at rates that deteriorate land quality. Land pollution can result either anthropogenic activities or natural activities. The major contaminants of land pollution are metalloids, petroleum hydrocarbon, radioactive elements, polyarom...
Microbial Based Land Restoration Handbook, Volume 1
Plant-microbe interaction is a powerful and promising link to mitigate the various kinds of stresses like drought, salinity, heavy metals, and pathogenic effects. It is more beneficial for crop improvement and sustainable approaches for reclamation of problematic soils. Taking a multidisciplinary approach, this book explores the recent uses of plant-microbe interactions in ecological and agricultural revitalization beyond normal agriculture practices and offers practical and applied solutions for the restoration of degraded land to fulfill human needs with food, fodder, fuel, and fiber. It provides a single comprehensive platform for soil scientists, agriculture specialists, ecologists, and ...
