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A collection of irreverent and poetic short works from legendary actor Vincent D’Onofrio This is not a story woven around plot, characters, and contrivance. Rather, it is what acclaimed actor Vincent D’Onofrio’s mind produces when on idle, when he is not thinking about servicing a story. His words are, in the purest sense, ideas that fall unexpectedly upon his head, “like an apple from a tree—dropping all at once,” though less about gravity and Newton’s apples, and more about levity. D’Onofrio’s thoughts and images—presented here in all their uninhibited glory—are humorous, honest, abundant, raw, and unfiltered. And all exceedingly enjoyable. The unique design—a paperback with flaps and Chinese binding, all contained in a full-color, hardcover slipcase—offers the book an artistic, collectible feel.
This book adopts a multidisciplinary approach to examine in detail a range of interesting new concepts in the diagnosis and therapy of pancreatic adenocarcinoma. It is divided into three parts. The first part provides an epidemiological and clinical overview of the disease, followed by an update on pathological findings, including new discoveries in the area of molecular biology. The second part, on diagnosis, offers detailed and comprehensive information on the advantages and disadvantages of different imaging techniques, including nuclear medicine and endoscopic ultrasound. The concluding part gives a panoramic overview of the various therapeutic options, from surgery to chemotherapy and palliative approaches based on interventional endoscopy and radiology. This book will be a valuable source of information for clinicians involved in the management of pancreatic adenocarcinoma and for all who are interested in updating their knowledge of the disease, including fellows and senior residents.
Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.
This issue reviews and updates a variety of topics in pancreatic imaging. Pearls on the Multiphasic CT of the pancreas are offered, along with the key MRI techniques for pancreatic imaging. Emerging CT, MR and US techniques for pancreatic evaluation (such as dual energy, DCMRI, spectroscopy, and US contrast) are elucidated. Ultrasound for pancreatic imaging is given a thorough review. An update on staging and resectability of pancreatic adenocarcinoma is discussed. Acute and chronic pancreatitis are reviewed, as well as cystic pancreatic lesions, congenital pancreatic anomalies, uncommon solid pancreatic neoplasms, and other pancreatic pathology. Post-operative imaging of the pancreas is discussed, and finally, an update on endoscopic techniques for the pancreas is provided.
Examines in detail the different clinical applications of microbubble-based contrast agents. Explains the principles underlying the use of contrast-specific imaging techniques and the examination methodology. Contains numerous high-quality illustrations, including many in color. Written by recognized experts.
The 50th anniversary of the discovery of quasars in 1963 presents an interesting opportunity to ask questions about the current state of quasar research. Formatted as a series of interviews with noted researchers in the field, each of them asked to address a specific set of questions covering topics selected by the editors, this book deals with the historical development of quasar research and discusses how advances in instrumentation and computational capabilities have benefitted quasar astronomy and have changed our basic understanding of quasars. In the last part of the book the interviews address the current topic of the role of quasars in galaxy evolution. They summarise open issues in understanding active galactic nuclei and quasars and present an outlook regarding what future observational facilities both on the ground and in space might reveal. Its interview format, the fascinating topic of quasars and black holes, and the lively recollections and at times controversial views of the contributors make this book both rewarding and a pleasure to read!
Mineral supplements are receiving a great deal of attention and experiencing a tremendous period of growth. Despite their popularity, questions continue to arise regarding the research behind their claims, the efficacy of different forms, and their overall safety. It is critical for the health care community and the general public to have an unbias
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized on US, CT or MR images. This atlas, which encompasses both the imaging and the pathology of pancreatic neoplasms, will therefore be invaluable in enabling radiologists and sonographers to understand the underlying pathology and in allowing pancreatic pathologists to understand the imaging translation. The emphasis in the atlas is very much on the pathological and imaging appearances, with most of the text concentrated at the beginning of the chapters. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and uncommon pancreatic neoplasms, including ductal adenocarcinoma, neuroendocrine neoplasms, intraductal papillary mucinous neoplasms, cystic neoplasms, metastases and lymphoma.
A comprehensive survey of the material culture of ninth-century Rome, drawing together disparate strands of evidence.