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Nuclear Receptors and Genetic Disease provides the first compilation of the role of nuclear hormones in health and disease and incorporates the latest breakthroughs in the field. It provides comprehensive reviews of the major receptors prepared by the acknowledged experts in each area. Each chapter provides information on the history, physiology, structure, mechanism of action, genetics, pathophysiology, disease diagnosis, and disease treatment for a particular nuclear receptor. Each chapter also includes a table showing all the known mutations of the respective nuclear receptor with the corresponding clinical disorder.Receptors included in this book are: - The Nuclear Receptor Superfamily - Thyroid Hormone Receptors - Estrogen and Progesterone Receptors - The Androgen Receptor - DAX-1 and Related Orphan Receptors - The Vitamin D Receptor - Retinoid Receptors - Mineralocorticoid and Glucocorticoid Receptors - Hepatocyte Nuclear Factor 4 a - Peroxisome Proliferator Activated Receptors - Coactivators and Corepressors
Up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.
This book analyzes how Chinese people use their time, including how busy Chinese seek a healthy work-life balance, how some children win from the outset in terms of education, and how people pursue quality of life outside of or after work. General readers will get a vivid and detailed impression of the way Chinese people spend their time, while researchers will find a wealth of phenomena and data for analysis from both economic and social perspectives. The research presented here was conducted in the context of the Chinese Time Use Survey (CTUS), a nationwide initiative launched by Inner Mongolia University in 2017. The CTUS covers 29 Chinese provinces, and the database contains the time use information of 30,591 people aged 3 years and over from 12,471 households. The survey collects information at three main levels: personal, family and community.
“Ambitious, fast-paced, fact-filled, and accessible.” —Science “A compelling case for why achieving the right balance of time with our families...is vital to the economic success and prosperity of our nation... A must read.” —Maria Shriver From backyard barbecues to the blogosphere, working men and women across the country are raising the same worried question: How can I get ahead at my job while making sure my family doesn’t suffer? A visionary economist who has looked at the numbers behind the personal stories, Heather Boushey argues that resolving the work–life conflict is as vital for us personally as it is essential economically. Finding Time offers ingenious ways to hel...
Down (law, U. of Florida) offers a progressive discussion of the economic, social, and legal aspects of fathering, making a case for greater emphasis on the social, nurturing behavior involved in parenting to redefine the role men play in the lives of their children. She also explores the barriers to such redefinition, including concepts of masculinity, the interconnections between fathers and mothers, male violence, and homophobia. Annotation copyrighted by Book News Inc., Portland, OR
By age 30, between 68 and 75 percent of young men in the United States, with only a high school degree or less, are fathers. This volume provides practical, policy-driven strategies to address the national epidemic of disadvantaged young fathers and the challenges they face in raising and supporting their children. National experts discuss the issues of immediate concern to those working to reconnect disengaged dads to their children and improve child and family economic and emotional well-being. Each chapter was presented at a working conference organized by Institute for Research on Poverty director, Tim Smeeding (University of Wisconsin–Madison), in coordination with the Columbia Univer...
Though there is considerable historical and anecdotal record for the use and efficacy of the cancer preventative properties of vegetables, fruits, and herbs, modern healthcare professionals require scientific evidence and verifiable results to make defensible decisions on the benefits, risks, and value of botanicals and their extracts in the preven
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version