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The Extracellular Matrix and the Tumor Microenvironment
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabo...
First Steps in the Origin of Life in the Universe
Proceedings of the Sixth Trieste Conference on Chemical Evolution, Trieste, Italy, 18-22 September 2000
Proteoglycans
This volume is a comprehensive and up-to-date collection of strategies, reproducible methods, and protocols for the in-depth analysis of Proteoglycans (PGs) and their glycan part, the GAGs. Chapters are divided into three parts detailing GAGs in biological specimens, protocols for the evaluation of the in vitro and in vivo effects of PGs/GAGs, and protocols for compounds related with the metabolic enzymes, epigenetic regulation, and PGs/GAGs-based inhibitors. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Cutting-edge and thorough, Proteoglycans: Methods and Protocols aims to provide information on the elucidated the structural and functional aspects of the complex matrix macromolecules such as the proteoglycans and glycosaminoglycans.
Medium Companies of Europe 1991/92
Volumes 1 & 2 Guide to the MEDIUM COMPANIES OF EUROPE 1991/92, Volume 1, arrangementofthe book contains useful information on nearly 4500 ofthe most important medium-sized companies in the European This book has been arranged in order to allow the reader to Community, excluding the UK, over 1500companies of which find any entry rapidly and accurately. are covered in Volume 2. Volume 3 covers nearly 2000 of the medium-sized companies within Western Europe but outside Company entries are listed alphabetically within each country the European Community. Altogether the three volumes of section; in addition three indexes are provided in Volumes 1 MEDIUM COMPANIES OF EUROPE now provide in and 3 on coloured paper atthe back of the book, and two authoritative detail, vital information on over 7900 key indexes in the case of Volume 2. companies in Western Europe. The alphabetical index in Volume 2 lists all the major MEDIUM COMPANIES OF EUROPE 1991/92, Volumes 1 companies in the UK. In this indexcompanies with names & 2 contain many ofthe most significant companies in such as A B Smith can be found listed as A B Smith and Europe. The area covered by these volumes, the European Smith, A B.
Medium Companies of Europe 1993/94
Volumes 1 & 2 Guide to the MAJOR COMPANIES OF EUROPE 1993/94, Volume 1, arrangement of the book contains useful information on over 4000 of the top companies in the European Community, excluding the UK, over 1100 This book has been arranged in order to allow the reader to companies of which are covered in Volume 2. Volume 3 covers find any entry rapidly and accurately. over 1300 of the top companies within Western Europe but outside the European Community Altogether the three Company entries are listed alphabetically within each country volumes of MAJOR COMPANIES OF EUROPE now provide in section; in addition three indexes are provided in Volumes 1 authoritative detail, vital information on o...
Life in the Universe
The year 2003 was the 50th anniversary of the seminal experiment of Stanley Miller. This was a unique opportunity for highlighting the current interest in this most interdisciplinary subject. The leading space agencies: the European Space Agency (ESA) as well as NASA, the American Space Agency, have planned missions that will elucidate some of the still unknown questions underlying research in the origin of life. New results are surpassing our ability to keep well informed: the reviews that we were presented at the Trieste meeting will bring the readers of this well-documented and timely book up to date in this fast-moving area. An important component of the conference was the review of the ...
The Upstairs Room
Really, we don't have to keep worrying about the time, Gordon. Let's just sit here together. Okay? For a little while. London is sinking, there's constant rain, and everyone is trying to escape. Gordon, an American writer, finds himself holed up in the attic room of a half-way house, awaiting forged papers and safe passage back to the States. He becomes trapped with Stella, a mysterious and seductive woman, and a teenage girl called Iris who, between them, take Gordon on an emotional journey through his past and into the present, forcing him to face the painful truth as to why he is there. David K. O'Hara's The Upstairs Room is a modern take on Sartre's play Huis Clos in which a man and two women find themselves confined together in a drawing room for eternity. First produced at the King's Head Theatre from 13 November to 8 December 2012 by Giddy Notion, The Upstairs Room is a compelling and well-written play.
Mechanical Design of Structural Materials in Animals
Mechanical Design of Structural Materials in Animals explores the principles underlying how molecules interact to produce the functional attributes of biological materials: their strength and stiffness, ability to absorb and store energy, and ability to resist the fatigue that accrues through a lifetime of physical insults. These attributes play a central role in determining the size and shape of animals, the ways in which they can move, and how they interact with their environment. By showing how structural materials have been designed by evolution, John Gosline sheds important light on how animals work. Gosline elucidates the pertinent theories for how molecules are arranged into macromole...
