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Brain Microtuble Associated Proteins
Brain Microtubule Associated Proteins lays a firm foundation for understanding the brain microtubule associated proteins and how they contribute to the neurodegeneration of Alzheimer's disease. Few other reference works contain within a single source such a complete treatment of this topic. The authors cast a broad net over the field by devoting the first four chapters to each of the major brain microtubule associated proteins, MAP1A, MAP1B, MAP2 and tau. Completing this background material are chapters on the cellular role of these proteins in developing neurons and the sorting of tau to axons. The remaining chapters focus on tau - its kinases, its phosphatases, and other post-translational modifications such as ubiquitination and glycation. The second part of the book takes a more practical approach and includes chapters on the purification of microtubule associated proteins, functional assays using gene-transfer experiments, immunofluorescence and video microscopic analysis. This book is intended not only to be a reference source for expert laboratories but also to provide information which will allow a novice in the field to choose the best method for a particular purpose.
Dendritic spines: from shape to function
One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dend...
International Review of Cytology
The acclaimed International Review of Cytology series presents current advances and reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Contributors to this volume areViatcheslav M. Mikhailov, Y.C. Wong, XH Wang, PMT Ling, Armin Hallmann, and Carlos G. Dotti.The acclaimed International Review of Cytology series presents current advances and reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes
The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in tur...
Apoptosis and Autophagy in Acute CNS Injuries: Mechanism and Treatment
Acute central nervous system (CNS) injuries include stroke, traumatic brain injury, and spinal cord injury. Early brain injury is a main cause of disability and death for patients of stroke or traumatic brain injury. The mechanisms of early brain injury after stroke and trauma are complex, and remain poorly understood. Neuronal cell death in the acute phase of CNS injuries is a central pathological process, which determines the long-term neurological deficits and prognosis.
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .
GENEALOGÍAS DE ANDES, ANTIOQUIA
GENEALOGÍAS DE ANDES, ANTIOQUIA (1855-1915). Autor: Aníbal Posada Correa Genealogías de los primeros pobladores del municipio de Andes (Antioquia, Colombia) Esta obra comprende la totalidad de las partidas de bautismo de Andes de los primeros 60 años, desde la inicial realizada en diciembre de 1855 (3 años después de la fundación de este municipio) hasta diciembre de 1915. En total son 28.243 registros bautismales sobre los cuales se formaron las respectivas genealogías, organizados de forma que se facilita al lector la búsqueda de personas y linajes específicos. Contiene además una presentación de la metodología utilizada, unas pocas anécdotas y fotografías, apuntes interesantes sobre esos primeros pobladores y sus historias genealógicas, y alguna información estadística de los registros genealógicos de este importante municipio cafetero de Colombia.
Official Gazette
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