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Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.
This is a unique book addressing the integration of risk methodology from various fields. It will stimulate intellectual debate and communication across disciplines, promote better risk management practices and contribute to the development of risk management methodologies. Individual chapters explain fundamental risk models and measurement, and address risk and security issues from diverse areas such as finance and insurance, the health sciences, life sciences, engineering and information science. Integrated Risk Sciences is an emerging discipline that considers risks in different fields, aiming at a common language, and at sharing and improving methods developed in different fields. Reader...
Summarizing molecular aspects, diagnostic as well as therapeutic issues, this book is the very first and most comprehensive on hereditary aspects of tumor diseases. All the contributors have been made fellows of the Ingrid zu Solms Foundation due to their outstanding achievements in scientific research, and they discuss here the latest aspects in the diagnosis, disease management, and treatment of hereditary tumor diseases and syndromes. A must-have ready reference for medical and biology students, MDs, PhDs, physicians, and researchers.
The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.
This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.
Recent scientific developments, in particular advances in pharmacogenetics and molecular genetics, have given rise to numerous predictive procedures for detecting predispositions to diseases in patients. This knowledge, however, does not necessarily promise benign results for either patients or health care professionals. The aim of this volume is to analyse issues related to prediction and prognosis as a burgeoning field of medicine, which is revolutionizing the way we understand and approach diagnosis and treatment. Combining epistemic and ethical reflection with medical expertise on contemporary practice and research, an interdisciplinary group of international experts critically examine a...
Das Fachbuch setzt die Reihe „Onkologie aktuell" konsequent interdisziplinär fort. Es führt Ärzte aus Klinik und Praxis umfassend und praxisnah durch alle wichtigen Themengebiete: von der Anatomie bis zur Molekularbiologie, von der Pathologie bis hin zur Diagnostik und Stadieneinteilung. Großen Raum nimmt eine anwendungsorientierte Übersicht zu den Behandlungsformen ein (mit Therapieplänen). Der Band informiert außerdem über Supportivtherapie und Nachsorge, Pharmaökonomie und Qualitätsmanagement und enthält alle relevanten Leitlinien.
Die LaborMedizin – mehr als eine Schnittstelle zwischen Patient und Diagnose ... Die Labormedizin als eines der innovativsten Hightech-Fachgebiete gewinnt – auch durch den Einsatz von Biomarkern – zunehmend Bedeutung in der Verlaufs- und Therapiebeurteilung sowie bei der Prognose von Erkrankungen. Das notwendige Fachwissen parat haben, gleichzeitig nah am Patienten sein – diesen Spagat müssen Sie täglich meistern: Mit der 3. Auflage der »LaborMedizin« bringen Sie Ihr Wissen rasch auf den neuesten Stand und verschaffen sich einen profunden Überblick über gängige Verfahren und neue Technologien. Von der Erfassung und Interpretation diagnostischer Laborparameter über Verlaufs- u...
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