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Hereditary Tumors
Summarizing molecular aspects, diagnostic as well as therapeutic issues, this book is the very first and most comprehensive on hereditary aspects of tumor diseases. All the contributors have been made fellows of the Ingrid zu Solms Foundation due to their outstanding achievements in scientific research, and they discuss here the latest aspects in the diagnosis, disease management, and treatment of hereditary tumor diseases and syndromes. A must-have ready reference for medical and biology students, MDs, PhDs, physicians, and researchers.
AACR 2019 Proceedings: Abstracts 1-2748
American Association for Cancer Research 2019 Proceedings: Abstracts 1-2748 - Part A
Regulators and Effectors of Small GTPases, Part G: Ras Family II
The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325, 329, and 332) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in the above-mentioned aspects of cell biology at the molecular level.
Cumulative Subject Index
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Supplements index volumes 33, 75, 95, 120, 140, 175, 199, 229, 265, 285, and 320 Subject index Contributor index
Tumor Microenvironment
This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Ethical Challenges in Cancer Diagnosis and Therapy
This book presents in detail the problems and ethical challenges in daily oncological practice. In western industrialized countries, roughly 25 percent of all citizens still die from cancer. Despite significant progress in basic science and in individual areas of clinical care, even in the 21st century, being diagnosed with cancer has lost none of its dread and can still be a death sentence. This situation raises many problems and challenges for medical ethics, e.g., the question of the benefits and risks of prevention programs, or the right to know and not to know. Clinical trials with cancer patients and quality assurance for surgery, radiotherapy and medication also pose a series of ethical dilemmas. Furthermore, cancer treatment is a psychological challenge not only for patients but also for physicians and caregivers. The issues of adequate pain management and good palliative care, of treatment limiting and the question of assisted suicide at the end of life also have to be considered. In order to reflect the subject’s diverse and multifaceted nature, the book incorporates legal, ethnographic, historical and literary perspectives into ethical considerations.
Matrix Proteases in Health and Disease
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
Human Placental Trophoblasts
Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critic
AACR 2016: Abstracts 1-2696
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.
Molecular Staging of Cancer
An explosion of information has occurred since scientists began to define the molecular events that describe the malignant transformation and progression of cells and their development towards a life-threatening metastatic disease. The First International Congress on Molecular Staging of Cancer, held in Munich in December 2001, aimed to establish an international platform of exchange among molecular biologists, cell biologists, tumor immunologists, and clinical and surgical oncologists. This network approach should be fruitful for both clinicians and researchers. The highlighted topics included tumor-associated proteolysis, minimal residual disease, new approaches for molecular diagnosis and targeting, and the first molecular staging models. One session focused on technology transfer, opening up a new field of funding for innovative concepts. Finally, the impact of molecular staging on clinical strategies was discussed.
