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Pathophysiology and Pharmacotherapy of Cardiovascular Disease
The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.
500 Days
In 500 Days, Kurt Eichenwald lays bare the harrowing decisions, deceptions and delusions of the 18 months that changed the world forever, as leaders raced to protect their citizens in the wake of 9/11. Eichenwald s immediate style and true-to-life dialogue puts readers at the heart of these historic events, from the Oval Office to 10 Downing Street, from Guantanamo Bay to the depths of CIA headquarters, from the al Qaeda training camps to the torture chambers of Egypt and Syria. Eichenwald exposes a world of secrets and lies that has remained hidden until now.
New Technologies for the Treatment of Coronary and Structural Heart Diseases
There has been significant progress in the field of interventional cardiology, from the development of newer devices to newer applications of technology, resulting in improved cardiovascular outcomes. The goal of this Special Issue is to update practicing clinicians and provide a comprehensive collection of original articles, reviews, and editorials. To this end, we invited state-of-the-art reviews, including reviews of new technology and therapeutics, as well as original research in this area to be considered for inclusion in this issue. Examples include the history and evolution of interventional techniques, reviews of specific devices and technologies for coronary artery disease (i.e., st...
Extracorporeal Membrane Oxygenation
"Extracorporeal Membrane Oxygenation : An Interdisciplinary Problem-Based Learning Approach" provides an overview of the latest techniques, management strategies, and technology surrounding the clinical use of ECMO. ECMO is a miniaturized heart-lung-machine that can be used to support patients with either acute respiratory and/or cardiocirculatory failure in numerous scenarios and can be a bridge to either heart or lung transplantation. This book focuseson educating clinicians about this complex but life-saving technology.
Regulation of Implantation and Establishment of Pregnancy in Mammals
Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.
Cholesterol Transporters of the START Domain Protein Family in Health and Disease
Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer and atherogenesis. This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows and endocrinology fellows on the research discovery process.
