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The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart...
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This book examines the multi-media explosion of contemporary political satire. Rooted in 18th century Augustan practice, satire’s indelible link with politics underlies today’s universal disgust with the ways of elected politicians. This study interrogates the impact of British and American satirical media on political life, with a special focus on political cartoons and the levelling humour of Australasian satirists.
“An attractive book . . . chock full with photos and drawings of all the planes that have been drawn and built in these years in the UK.” —AviationBookReviews.com It could be argued that the heyday of British military aircraft flight testing began in the 1940s, and continued throughout the three decades that followed, during the so-called Cold War period. As such, the authors have purposely chosen to focus on the first 30 years, The Golden Years, 1945 to 1975, from the end of World War Two until the mid-1970s. This was arguably the most exciting period with many wonderful and new types rubbing shoulders with wartime and immediate postwar designs that were utilized for development purpo...
This book considers the place and value of knowledge in contemporary society. “Knowledge” is not a self-evident concept: both its denotations and connotations are historically situated. Since the Enlightenment, knowledge has been a matter of discovery through effort, and “knowledge for its own sake” a taken-for-granted ideal underwriting progressive education as a process which not only taught “for” and “about” something, but also ennobled the soul. While this ideal has not been explicitly rejected, in recent decades there has been a tacit move away from a strong emphasis on its centrality, even in Higher Education. The authors address the values that inform knowledge product...
During their lifetime, especially when growing and dividing, cells go through various steps of the cell cycle. Knowledge of the individual steps of the cell cycle will help us understand the development of a variety of diseases better, including cancer, and also to design new drugs against it. New techniques for studying the molecular basis of these processes have recently been developed and are described in detail in this manual. A glossary helps the reader to cope with the complex cell cycle terminology.