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ABC Transporters - 40 Years on
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and t...
Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria
The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/docu...
Excitonic Effects and Bandgap Instabilities in Perovskite Solar Cells
Perovskite solar cells are the new hope of next-generation photovoltaic concepts for sustainable energy generation. Regarding their favorable optoelectronic properties, bound electron-hole pairs (so-called excitons) play a significant role and are thoroughly investigated utilizing various spectroscopic methods. Moreover, bandgap instabilities caused by segregation effects in mixed perovskites are analyzed in detail using electroreflectance spectroscopy and structural characterization techniques.
Advances in Spatial and Temporal Databases
The Seventh International Symposium on Spatial and Temporal Databases (SSTD 2001), held in Redondo Beach, CA, USA, July 12{15, 2001, brought together leading researchers and developers in the area of spatial, temporal, and spatio-temporal databases to discuss the state of the art in spatial and temporal data management and applications, and to understand the challenges and - search directions in the advancing area of data management for moving objects. The symposium served as a forum for disseminating research in spatial and temporal data management, and for maximizing the interchange of knowledge among researchers from the established spatial and temporal database com- nities. The exchange ...
High Performance Computing in Science and Engineering '19
This book presents the state-of-the-art in supercomputer simulation. It includes the latest findings from leading researchers using systems from the High Performance Computing Center Stuttgart (HLRS) in 2019. The reports cover all fields of computational science and engineering ranging from CFD to computational physics and from chemistry to computer science with a special emphasis on industrially relevant applications. Presenting findings of one of Europe’s leading systems, this volume covers a wide variety of applications that deliver a high level of sustained performance. The book covers the main methods in high-performance computing. Its outstanding results in achieving the best performance for production codes are of particular interest for both scientists and engineers. The book comes with a wealth of color illustrations and tables of results.
