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Recent Advances in the Understanding of Hepatocellular Carcinogenesis, 2nd edition
Hepatocellular carcinoma (HCC) is the most common cancer of the liver and the third most cause of cancer-related deaths worldwide. The 5-year survival of HCC is less than 20%, making HCC the second most lethal malignancy; the first being pancreatic cancer. HCC usually occurs in patients with chronic liver disease in association with a variety of risk factors, including chronic liver infection with hepatitis B virus or hepatitis C virus; excessive consumption of alcohol; overeating, obesity, and nonalcoholic fatty liver disease; other metabolic liver diseases including Wilson’s disease, hemochromatosis, and alpha-1-antitrypsin deficiency; and environmental toxins such as aflatoxins. Tobacco...
The Mononuclear Phagocyte System in Infectious Disease
The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strate...
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Inflammation, 4 Volume Set
Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Legislative Documents
Contains the reports of state departments and officials for the preceding fiscal biennium.
Eco-Restoration of Polluted Environment
The book Eco-Restoration of the Polluted Environment: A Biological Perspective explores recent advances in biological strategies for the remediation of polluted environments, including soil, water, and air. It covers bioremediation of heavy metals, radioactive waste, and waste gases, which are believed to be bottleneck problems for researchers working in this field. The book contains separate chapters on genetic engineering technology for enhancement of the bioremediation potential of bioresources and the role of biosurfactants, enzymes, and exo-polysaccharides for bioremediation of polluted environments, along with basic aspects of eco-restoration by microorganisms. It summarizes the signif...
Dendritic Cell and Macrophage Nomenclature and Classification
The mononuclear phagocyte system (MPS) comprises dendritic cells (DCs), monocytes and macrophages (MØs) that together play crucial roles in tissue immunity and homeostasis, but also contribute to a broad spectrum of pathologies. They are thus attractive therapeutic targets for immune therapy. However, the distinction between DCs, monocytes and MØ subpopulations has been a matter of controversy and the current nomenclature has been a confounding factor. DCs are remarkably heterogeneous and consist of multiple subsets traditionally defined by their expression of various surface markers. While markers are important to define various populations of the MPS, they do not specifically define the ...
