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Ligand-Binding Assays
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-b...
Kritika: Essays on Intellectual Property
The fields of intellectual property have broadened and deepened in so many ways that commentators struggle to keep up with the ceaseless rush of developments and hot topics. Kritika: Essays on Intellectual Property is a series that is designed to help authors escape this rush. It creates a forum for authors who wish to more deeply question, investigate and reflect upon the evolving themes and principles of the discipline.
Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System
Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on ner...
Investigation of Membrane-Located Receptors
Prefaces tend to be platitudinous and unconducive to perusal. To this hardened Editor, the appearance of the book represents the end of a stamina-testing saga surpassing any past experience. Amongst the numerous authors - a notably eminent bevy - some were angelic and others suffered harassment to produce, amidst day-to-day pressures, an eventual article in the cause of receptor investigation; few took exception to the strong editing that their material underwent. The reader of this book will be interested rather in its aims and ba- ground.- Does it merit a n his bookshelf? The book is not a 'Proceedings', but has sponsored-meeting parentage. Wi th company support, notably from BetaHED Pharm...
Molecular and Cellular Aspects of Reproduction
Recently, considerable attention has been focused on studies of membrane structure and function--involvement of cell surface components in intercellular interaction, in translocation of ligands and receptors across cell membranes, and in the immunological properties of cells and gene expression and regulation. These investigations have led to the development of powerful technical tools which can be of immense value in the study of animal and human reproduction. The investigations of problems such as gamete interaction, fertilization, embryo implantation, and development have reached a stage where further meaningful progress in their understanding does not seem likely unless the conventional ...
Women in Breast Cancer: 2022, volume II
We are delighted to present the Frontiers in Oncology "Women in Breast Cancer” Volume II series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
Improving Stress Resilience in Plants
Improving Stress Resilience in Plants: Physiological and Biochemical Basis and Utilization in Breeding addresses the urgent need for improved understanding of major plant stress tolerance mechanisms, the identification of the genes and gene products that are key to improving those mechanisms and means of optimizing those genes through molecular approaches. With a focus on plant physiological and biochemical attributes at both cellular and whole plant levels, this book includes the latest information on crosstalk between the various signaling molecules and quantitative trait locus (QTL). Further, it explores the extension of these mechanisms to breeding approaches, confirming overall understa...
Ethylene’s Role in Plant Mineral Nutrition
Terrestrial plants are sessile organisms that, differently from animals, can not move in searching of the nutrients and water they need. Instead, they have to change continuously their physiology and morphology to adapt to the environmental changes. When plants suffer from a nutrient deficiency, they develop physiological and morphological responses (mainly in their roots) aimed to facilitate the acquisition and mobilization of such a nutrient. Physiological responses include some ones like acidification of the rizhosphere and release of chelating agents into the medium; and morphological responses include others, like changes in root architecture and development of root hairs. The regulatio...
