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Membranes to Molecular Machines
  • Language: en
  • Pages: 307

Membranes to Molecular Machines

Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This...

The Black Box of Biology
  • Language: en
  • Pages: 529

The Black Box of Biology

In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology w...

Biological Individuality
  • Language: en
  • Pages: 368

Biological Individuality

Introduction: working together on individuality / Lynn K. Nyhart and Scott Lidgard -- The work of biological individuality: concepts and contexts / Scott Lidgard and Lynn K. Nyhart -- Cells, colonies, and clones: individuality in the volvocine algae / Matthew D. Herron -- Individuality and the control of life cycles / Beckett Sterner -- Discovering the ties that bind: cell-cell communication and the development of cell sociology / Andrew S. Reynolds -- Alternation of generations and individuality, 1851 / Lynn K. Nyhart and Scott Lidgard -- Spencer's evolutionary entanglement: from liminal individuals to implicit collectivities / Snait Gissis -- Biological individuality and enkapsis: from Mar...

Crossing the Boundaries of Life
  • Language: en
  • Pages: 367

Crossing the Boundaries of Life

"The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cytologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to synthesize proteins to theorize how proteins in the cell communicate spatially, an idea he called signal hypothesis. Over the next 20 years, Blobel and other scientists were able to dissect this proce...

Explaining Photosynthesis
  • Language: en
  • Pages: 354

Explaining Photosynthesis

  • Type: Book
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  • Published: 2015-06-17
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  • Publisher: Springer

Recounting the compelling story of a scientific discovery that took more than a century to complete, this trail-blazing monograph focuses on methodological issues and is the first to delve into this subject. This book charts how the biochemical and biophysical mechanisms of photosynthesis were teased out by succeeding generations of scientists, and the author highlights the reconstruction of the heuristics of modelling the mechanism—analyzed at both individual and collective levels. Photosynthesis makes for an instructive example. The first tentative ideas were developed by organic chemists around 1840, while by 1960 an elaborate proposal at a molecular level, for both light and dark react...

The Long Arm of Moore's Law
  • Language: en
  • Pages: 300

The Long Arm of Moore's Law

  • Type: Book
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  • Published: 2016-12-09
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  • Publisher: MIT Press

How, beginning in the mid 1960s, the US semiconductor industry helped shape changes in American science, including a new orientation to the short-term and the commercial. Since the mid 1960s, American science has undergone significant changes in the way it is organized, funded, and practiced. These changes include the decline of basic research by corporations; a new orientation toward the short-term and the commercial, with pressure on universities and government labs to participate in the market; and the promotion of interdisciplinarity. In this book, Cyrus Mody argues that the changes in American science that began in the 1960s co-evolved with and were shaped by the needs of the “civilia...

The Circulation of Penicillin in Spain
  • Language: en
  • Pages: 246

The Circulation of Penicillin in Spain

  • Type: Book
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  • Published: 2017-12-18
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  • Publisher: Springer

This book reconstructs the early circulation of penicillin in Spain, a country exhausted by civil war (1936–1939), and oppressed by Franco’s dictatorship. Embedded in the post-war recovery, penicillin’s voyages through time and across geographies – professional, political and social – were both material and symbolic. This powerful antimicrobial captivated the imagination of the general public, medical practice, science and industry, creating high expectations among patients, who at times experienced little or no effect. Penicillin’s lack of efficacy against some microbes fueled the search for new wonder drugs and sustained a decades-long research agenda built on the post-war concept of development through scientific and technological achievements. This historical reconstruction of the social life of penicillin between the 1940s and 1980s – through the dictatorship to democratic transition – explores political, public, medical, experimental and gender issues, and the rise of antibiotic resistance.

The Arts of the Microbial World
  • Language: en
  • Pages: 334

The Arts of the Microbial World

"The Arts of the Microbial World explores how Japanese scientists and skilled workers sought to use the microbe's natural processes to create new products, from soy-sauce mold starters to MSG and from vitamins to statins. In traditional brewing houses as well as in the food, fine chemical, and pharmaceutical industries across Japan, they showcased their ability to deal with the enormous sensitivity and variety of the microbial world. Victoria Lee's careful study offers a lush historical example of a society where scientists asked microbes for what they termed "gifts." Lee's story ranges from the microbe's integration into Japan as an imported concept to its precise application in recombinant...

Information
  • Language: en
  • Pages: 902

Information

"Information technology shapes nearly every part of modern life, and debates about information--its meaning, effects, and applications--are central to a range of fields, from economics, technology, and politics to library science, media studies, and cultural studies. This rich, unique resource traces the history of information with an approach designed to draw connections across fields and perspectives, and provide essential context for our current age of information. Clear, accessible, and authoritative, the book opens with a series of articles that provide a narrative history of information from premodern practices to twenty-first-century information culture. This section focuses on major ...

Spoils of Knowledge
  • Language: en
  • Pages: 231

Spoils of Knowledge

  • Type: Book
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  • Published: 2023-01-16
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  • Publisher: BRILL

Emma Hagström Molin uncovers the history of a most peculiar heritage: seventeenth-century plunder in the form of archival documents, manuscripts and books preserved in Swedish archives and libraries.