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Published by Sinauer Associates, an imprint of Oxford University Press. Provides descriptions of the methods and tools used in molecular population genetics, which has combined advances in molecular biology and genomics with mathematical and empirical findings to uncover the history of natural selection and demographic shifts in many organisms.
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Here are all known instances of the animated Peter Lorre in theatrical cartoons, TV shows, commercials, video games, and more, including abandoned projects, coincidences, connections, and apocrypha. Illustrated. Includes index, notes, and bibliography.
From the bestselling author of The Lamb's Supper comes an illuminating work on the Catholic Eucharist and its link to the Jewish Passover meal. “Read this book. And don’t just read it. Pray about it. Reflect on it. And share it with others.”—Brant Pitre, author of The Case for Jesus In this brilliant book—part memoir, part detective story, and part biblical study—Scott Hahn opens up new vistas on ancient landscapes while shedding light on his own enduring faith journey. The Fourth Cup not only tracks the author’s gradual conversion along the path of Evangelicalism to the doorsteps of the Catholic faith, but also explores the often obscure and misunderstood rituals of Passover a...
Bestselling author and theologian Scott Hahn offers a commentary on 1 and 2 Chronicles as a liturgical and theological interpretation of Israel's history.
Emphasizing the role of kinship, labor, and networks in the African American community, the author retraces six generations of black struggles since the end of the Civil War, revealing a "nation" under construction.
After the many bureaucratic changes that followed the passing of the Affordable Care Act (Obamacare) and other legislation, patient care has become secondary to satisfying the whims of government and giant insurance company administrators, who are in total control. The result is a web of complicated rules and misguided programs whose chief effect has been to distract doctors and nurses from their proper focus on patient care. Access to health care now depends on the ability of patients, doctors, and nurses to navigate in and around this cumbersome and ever-changing system. Written by a practicing doctor and based on years of real-life experience, Distracted takes the unique view that it is not the American health care system that is broken—the problem lies in the administration of health care. The solution is simplicity where there is complexity. The solution is an elegant use of health information technology to foster improved care. It is putting control of health care decisions back with those who know best, patients and their health care teams. The solution is caring for patients with fewer distractions.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics.
A comprehensive philosophically grounded argument for the use of social welfare functions as a framework for governmental policy analysis.