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Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
Innovative Geschäftsmodelle sind für den Erfolg eines Unternehmens entscheidend, da das Unternehmensumfeld einem ständigen Wandel unterliegt. Eine höhere Transparenz der Leistungen von Unternehmen, Preiswettbewerbe, geringere Differenzierungsmöglichkeiten ausschließlich mit Produkten und Dienstleistungen und die unzureichende Nutzung von Potenzialen im technologischen Bereich prägen den Alltag. Das vorliegende Kompendium zeigt wesentliche Grundlagen und Vorgehensweisen der Geschäftsmodell-Innovation auf. Neben aktuellen Themen, wie z.B. die Einbettung von Geschäftsmodellen in den strategischen und kulturellen Kontext eines Unternehmens, enthält das Kompendium Fallstudien erfolgreicher Geschäftsmodell-Innovationen. Checklisten und ein Glossar runden das Kompendium ab. Die Leserinnen und Leser des Kompendiums erhalten aktuelle Ergebnisse aus Theorie und Praxis zum Thema Geschäftsmodell-Innovation. Wissenschaftler können die Inhalte nutzen, um die Forschung weitervoranzutreiben; Praktiker erhalten die Möglichkeit, ihr Geschäftsmodell anzupassen bzw. neue Geschäftsmodelle zu entwickeln und sich somit den veränderten Anforderungen zu stellen.
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This book breaks new ground, taking business history where it has only reluctantly gone in the past. The introduction reviews the small, but growing, literature, based on fresh archival materials, which investigates the history of business organisation in the Global East, or the Second World in the Cold War. It argues that there is already a great variety of approaches that go beyond the view of the Soviet-style firm as primarily a production function. Focusing on East Germany and Yugoslavia, seven chapters showcase new directions in the field, and demonstrate that the combination of business history with other historical and disciplinary approaches can help unpack the diversity of historica...
A Handbook of Lattice Spacing and Structures of Metals and Alloys is a 12-chapter handbook that describes the structures and lattice spacings of all binary and ternary alloys. This book starts with an introduction to the accurate determination of structure and lattice spacings. The subsequent chapters deal with the role of structure determination and lattice spacings in alloy formation, as well as the application of this determination to the equilibrium diagram examination. These topics are followed by discussions on the correlation of lattice spacing and magnetic property, including X-ray crystallographic data for those structures allotted a “Strukturbericht type. The remaining chapters contain table lists information about the crystal structures, densities, and expansion coefficients of the elements. These chapters also present further information about lattice spacing and structure determination on metals in alphabetical order. This book is of value to physicists and metallurgists.