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Gene Therapy
I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection...
Structural Biology and Functional Genomics
Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research. This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.
Rectal Cancer
This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
Dilated Cardiomyopathy
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Gene Therapy for Renal Diseases and Transplantation
Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in ti...
From Bench to Bedside, to Track & Field
This book represents a unique contribution to the debate on enhancement technologies as it spans from the bench of molecular biology where the technologies are being developed, to the bedside of a clinical trial where they are used for selective reproduction or for first-in-human gene therapy studies, to the track & field where they are being applied to enhance human athletic performance. These investigations address current debates regarding the resurgence of eugenics in relation to genetic technologies, and provide a clear and much needed ethical autopsy of contemporary genetic practices.
AHA Scientific Sessions 2019 - Final Program
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
