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This lavishly illustrated atlas provides indispensable information to clinicians, geneticists and visual scientists working with inherited retinal diseases. It is filled with high-quality images, up-to-date genetic information and comprehensive electrophysiology. The data for each individual disorder have been summarised in an accessible, reader-friendly format for easy reference. The illustrations include colour fundus photographs, fluorescein angiograms, OCT scans, electrophysiological studies and pedigrees. The editors and authors are well-known experts in the field and have drawn upon their extensive experience to produce this unique atlas.
The Milan Briefcase unfolds against the backdrop of the continuing, all but forgotten war in eastern Ukraine and an ailing Russian economy whose helmsmen are losing the electorate’s faith in their competence. It is a tale of machinations within clandestine corridors of power, where manipulation of public opinion is just one of the ruses, together with systematic dumbing down, employed by Machiavellian puppet masters towards achieving unpalatable ends. When classified Secret Service documents left inadvertently in a London minicab fall into private hands and are whisked away to a quiet European principality, the fuse is lit to a chain of events setting British and American intelligence serv...
Presents a selection of Poe's tales and poems with in-depth marginal notes elucidating his sources, obscure words and passages, and literary, biographical, and historical allusions.
Traceability describes the ability of stakeholders to understand and follow relationships between artifacts that play some role in software development. It is essential for many development tasks, e.g., quality assurance, requirements management, or software maintenance. Aiming to overcome various deficiencies of existing traceability concepts, this book presents a universal approach describing required features of traceability solutions. This includes a technology-independent, generic template for the definition of semantically rich traceability relationship types and technology-independent patterns for the retrieval of traceability information, reflecting generic problems common to traceability applications. The universal approach is implemented on the basis of two concrete technologies which facilitate comprehensive traceability: the TGraph approach and OWL ontologies. The applicability of the approach is shown by three case studies dealing with the reuse of software artifacts, process model refinement, and requirements management, respectively.
This book contains the refereed proceedings of the 14th International Symposium on Mathematical Morphology, ISMM 2019, held in Saarbrücken, Germany, in July 2019. The 40 revised full papers presented together with one invited talk were carefully reviewed and selected from 54 submissions. The papers are organized in topical sections on Theory, Discrete Topology and Tomography, Trees and Hierarchies, Multivariate Morphology, Computational Morphology, Machine Learning, Segmentation, Applications in Engineering, and Applications in (Bio)medical Imaging.
An innovative look at the process and development of nineteenth-century modernism.
This book provides an overview on the organization and function of the microtubule cytoskeleton, which is essential to many cellular processes and profoundly linked to a range of human diseases. Covering basic concepts as well as molecular details, the book discusses how microtubules are nucleated and organized into ordered arrays, at different cell cycle stages and in distinct cell types. In addition, the book highlights how defects in the microtubule cytoskeleton are linked to diseases such as neurodevelopmental disorders. The book is intended for students, graduates and more senior researchers in cell and developmental biology as well as for medical doctors.
In this magisterial history of intellectual life, Michael O'Brien analyzes the lives and works of antebellum Southern thinkers and reintegrates the South into the larger tradition of American and European intellectual history. O'Brien finds that the evolution of Southern intellectual life paralleled and modified developments across the Atlantic by moving from a late Enlightenment sensibility to Romanticism and, lastly, to an early form of realism. Volume 1 describes the social underpinnings of the Southern intellect by examining patterns of travel and migration; the formation of ideas on race, gender, ethnicity, locality, and class; and the structures of discourse, expressed in manuscripts a...