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Glioblastoma multiforme (GBM) is a uniformly fatal primary brain tumour. Whilst many therapeutic interventions have been studied pre-clinically very few new therapies have been approved for the use of GBM therapy. These tumours present a unique challenge due to their location within the brain, making delivery of therapeutic interventions challenging. Active immunotherapy represents an attractive avenue for therapy, with activated immune cells being shown to cross the blood brain barrier and penetrate brain tumours. Despite several advances being made in numerous other cancer types, many immunotherapeutic interventions in GBM have failed to make it past phase 3 clinical trials and as of now (2022) no immunotherapeutic interventions have been approved for the therapy of GBM.
Your resource for advancements in equipment and technology for coal preparation. With recent reductions in U.S. coal production, it is important for coal preparation engineers and practitioners to be aware of advances in technology to improve plant efficiency and productivity in cost-effective ways. Challenges and Opportunities in Coal Preparation provides both a domestic and international perspective on these new technologies and includes papers from industry leaders in the United States, as well as Australia and South Africa. Opportunities for overall plant efficiency improvements and new technologies that address many aspects of the coal preparation value chain—from pre-sorting to coarse and fine coal cleaning to dewatering—are presented. Read the latest thinking from industry experts in this handy reference that will assist current and future plant engineers and designers in achieving higher efficiency and productivity.
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In volumes1-8: the final number consists of the Commencement annual.
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