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Improving Responses to Immunotherapy in Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is a uniformly fatal primary brain tumour. Whilst many therapeutic interventions have been studied pre-clinically very few new therapies have been approved for the use of GBM therapy. These tumours present a unique challenge due to their location within the brain, making delivery of therapeutic interventions challenging. Active immunotherapy represents an attractive avenue for therapy, with activated immune cells being shown to cross the blood brain barrier and penetrate brain tumours. Despite several advances being made in numerous other cancer types, many immunotherapeutic interventions in GBM have failed to make it past phase 3 clinical trials and as of now (2022) no immunotherapeutic interventions have been approved for the therapy of GBM.
The Art of Theoretical Biology
This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision.
Molecular and Cellular Physiology of Neurons
This book provides a comprehensive and up-to-date account of what we now know--and what we want to know and can reasonably expect to discover in the near future--about the functioning of the brain at the level of molecules and cells. It takes readers from the fundamentals to the most sophisticated concepts and latest discoveries --from membrane potentials to recent experiments on voltage-gated ion channels, from descriptions of receptors, G proteins, effector molecules, and secondary messengers to an account of our current understanding of long-term potentiation.
Challenges and Opportunities in Coal Preparation
Your resource for advancements in equipment and technology for coal preparation. With recent reductions in U.S. coal production, it is important for coal preparation engineers and practitioners to be aware of advances in technology to improve plant efficiency and productivity in cost-effective ways. Challenges and Opportunities in Coal Preparation provides both a domestic and international perspective on these new technologies and includes papers from industry leaders in the United States, as well as Australia and South Africa. Opportunities for overall plant efficiency improvements and new technologies that address many aspects of the coal preparation value chain—from pre-sorting to coarse and fine coal cleaning to dewatering—are presented. Read the latest thinking from industry experts in this handy reference that will assist current and future plant engineers and designers in achieving higher efficiency and productivity.
