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Death Receptors and Cognate Ligands in Cancer
Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.
Advances in TNF Family Research
The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
Catalog of Copyright Entries, Third Series
The record of each copyright registration listed in the Catalog includes a description of the work copyrighted and data relating to the copyright claim (the name of the copyright claimant as given in the application for registration, the copyright date, the copyright registration number, etc.).
Bioprobes
Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. "Bioprobes" is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.
Peru
Detailed coverage is given of the breathtaking Machu Picchu and other archaeological sites, along with extensive background on Peru's history, from pre-Incan cultures to the present day. of color photos. 63 maps.
