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Advances in TNF Family Research
The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
Necrotic Cell Death
Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
Failure to Fire
Failure to Fire takes place in 2015 - 2016 when al Qaeda smuggles teams of terrorists into the United States by crossing the southern border and by coming ashore in the Northeast. Their goal, shut down the U.S. air transportation system using man-portable air defense systems (MANPADS). The president of the U.S. does not believe, now that his administration has eliminated Osama bin Laden, that al Qaeda is capable of such an attack despite prima facie evidence that MANPADS have been found in the U.S. Derek Almer’s contacts at the CIA arranged for him to create a small think tank to operate under the radar and identify who is bringing the missiles into the country and develop a plan to preven...
Regulated Cell Death Part B
Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches
PhoneGap By Example
Use PhoneGap to apply web development skills and learn variety of cross-platform mobile applications About This Book Utilize the robust features of the mobile hybrid approach to develop, test, and publish mobile applications using the PhoneGap framework Use your web skills for hybrid mobile application development and deliver to many mobile platforms without rewriting the code Develop a set of ready-to-use mobile applications with this practical, comprehensive, step-by-step guide Who This Book Is For If you are a web developer with some experience in development of single page applications and want to enter the world of mobile applications, then this technology and book is ideal for you. Sin...
Body Messages
Whether classified as regulators of inflammation, metabolism, or other functions, a distinctive set of molecules enables the body to convey information from one cell to another. Giamila Fantuzzi offers a primer on molecular mediators that coordinate complex bodily processes, and explores the consequences of their discovery for modern medicine.
Encyclopedia of Immunobiology
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
