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Targeting Oral Cancer
This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.
Textbook of Hemophilia
The editors have included new authors and topics, and several chapters from second edition have been dropped. The overall organisation of the textbook has been changed in the light of changes of emphasis over the past 10 years. References have been restricted to create an overall succinct and comprehensive volume. A chapter on novel therapies in clinical trials or pre-clinical trials will be added at the time of going to press. The editors have consolidated the gene therapy section from three to two chapters, and retitled the Section, The Future of Haemophilia Therapy. The chapter on Old Age in Haemophilia has been extended to include more about survivorship with HCV/HIV and perioperative management (+/- anticoagulation in association with post-stent/cardiothoracic surgery following MI). Two areas that particularly needed reorganisation and rewriting were Inhibitors and Treatment to incorporate new products and future directions. Major new initiatives such as EUHASS have been incorporated. Furthermore, Ethical aspects of hemophilia care now merits a chapter on its own.
Nonmalignant Hematology
This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related...
Inborn Errors of Metabolism, An Issue of Pediatric Clinics of North America
The guest editors have compiled expert authors to provide current updates on the clinical management of inborn errors of metabolism. Authors have contributed clinical review articles on the following topics: Inborn errors of metabolism overview: pathophysiology, manifestations, evaluation, and management; Inborn errors of metabolism with acidosis: organic acidemias and defects of pyruvate and ketone body metabolism; Inborn errors of metabolism with hyperammonemia: urea cycle defects and related disorders; Inborn errors of metabolism with hypoglycemia: glycogen storage diseases and gluconeogenesis defects; Inborn errors of metabolism with myopathy: defects of fatty acid oxidation and carnitin...
The Value of Things
L'éditeur indique : "This book explores how the Mayans gave value to commodities through the lens of anthropology and archaeology."
Pediatric Emergency Medicine, An Issue of Pediatric Clinics of North America
Clinical decision making in the emergency department; Recent advances in the recognition, evaluation and management of pediatric sepsis; Evaluation and management of the adult patient presenting to a pediatric ED; Critical care in the pediatric ED; Point of care testing in the ED: Implications, impact and future directions; Child abuse and conditions that mimic them; Indications and interpretation of common investigations/tests in the ED; Recent advances in pediatric concussion and mild traumatic brain injury; Pediatric emergency care: Impact on healthcare and implications for policy; Clinical decision rules in the pediatric ED; Pediatric urgent care: The good, the bad and the ugly; Advances in medical education and implications for the pediatric ED workforce; Quality and safety in pediatric ED; Optimizing resources and impact of lean processes on ED operations; Pediatric readiness and disaster management; Recent advances in technology and its applications to pediatric emergency care
Recent Advances in Thrombosis and Hemostasis
Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms f...
Pediatric Pharmacology and Drug Therapy, An Issue of Pediatric Clinics of North America
Dr. Aranda is an top expert in the area of pharmacology in the pediatric population. His issue has knowledgeable authors presenting clinical reviews on a wide variety of topics, from "hot areas " of drug therapy to drug abuse in children as well as current areas of debate in neonatal drug therapy. Articles are devoted to the following topics: New and Current Drug Therapies For Asthma In Children; Psychopharmacology Of Bipolar Disorders in Children and Adolescents; Designer Drug Abuse in School Children; Dietary Supplements in Children; Anticoagulant Therapies in Children; New Antimicrobials for Gram-Positive Infections in Children; Probiotics in Newborns And Children; Anticonvulsant Therapie...
The Unfolded Protein Response and Cellular Stress, Part C
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights - This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation - The authors explain how these methods are able to provide important biological insights
