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The Power of Prions
The remarkable family of proteins that can make us very ill—but can also be linked to long-term memory, immunity, and the origin of life Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson’s and Alzheimer’s—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and—in an extraordinary finding—the part they may have played in the beginni...
Methods in Virology
Methods in Virology, Volume VII focuses on the methods used in virology, including radioimmunoassays, microscopy, hybridization, and mutagenesis. The selection first elaborates on monoclonal antibody techniques applied to viruses; competition radioimmunoassays for characterization of antibody reactions to viral antigens; and enzyme immunosorbent assays in plant virology. Discussions focus on the principles of enzyme immunosorbent assay, choice of enzyme and preparation of conjugate, determination of immunoglobulin class, and maintenance and specificity testing of hybridomas. The text then elaborates on electron microscopy for the identification of plant viruses in in vitro preparations and c...
Archaeological Salvage Projects, 1974
In 1974, the Salvage Section, Archaeological Survey of Canada, National Museum of Man, instituted nine archaeological salvage projects across the country. These ranged from a brief survey of one portion of the Mackenzie Highway to the extensive survey and excavations on the Suffield Military Reserve in southeastern Alberta. This volume contains summary articles describing these projects.
UCSF Magazine
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Autophagy in Infection and Immunity
Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (s...
Cancer Research Supported Under BIOMED 1
The pace of discovery, within the EU, of scientific aspects of cancer research and of developments in the clinical field is so rapid that it is sometimes difficult to keep abreast. This brief overview attempts to highlight some of the advances in the field, as part of BIOMED programme funded research and specific results due to the co-operative spirit established by the scientific community. It is particularly worth noting the financial investment of 35 million ECU in the current programme, has d as a catalyst in attracting a large number of Member States funded research in pooling their collective knowledge base.
An Epidemic of Absence
Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn's disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that's because it has--to levels never before seen in human history. These days no fewer than one in fiv, and likely more, Americans suffer from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works. In the past 150 years, improved sanitation,...
Journal of Virology
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Proceedings of the National Academy of Sciences of the United States of America
The Proceedings of the National Academy of Sciences (PNAS) publishes research reports, commentaries, reviews, colloquium papers, and actions of the Academy. PNAS is a multidisciplinary journal that covers the biological, physical, and social sciences.
Arenaviruses II
The second volume of Arenaviruses deals with the biology and the pathogenesis of arenaviruses primarily through the study of LCMV. The fundamental observation of MHC restriction and CD8 cytotoxic T lymphocyte killing derived initially from studies with LCMV in the mouse, and has been expanded to studies of most human pathogens, viral, bacterial, parasitic, as well as events in cancer. The scope and importance of this observation was recognized by awarding the Nobel Prize in 1996 to Rolf Zinkernagel and Peter Doherty, long-time workers in the field of LCMV and arenavirus biology. Since then, many of the principles for understanding viral pathogenesis and biology of animal viruses have been defined, in great part, from the lessons learned by studying LCMV. Those lessons and their implications are the subject of this second volume on the arenaviruses.
