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Challenges Associated with Identifying Preclinical Animal Models for the Development of Immune-based Therapies
There hasn’t been a better time to be a drug developer for immune-based therapies than the past couple of decades. We have seen an explosion in immune-based therapies for cancer, autoimmune and infectious diseases, metabolic diseases and diseases and disorders of the nervous system. The modalities of these immune-based therapies span small molecules, biologics, and gene and cell therapeutic approaches. Significant advances have been made in optimizing drug design for its specificity for the target, characterizing the mode of action in in vitro assays, and ensuring safety and manufacturability. However, an area of challenge that remains is identifying animal models for evaluating efficacy and pharmacokinetics/pharmacodynamics relationship that are predictive of drug effects in humans. Discussion on this topic is warranted as examples of failures of translation from animal models to humans provide us an opportunity to learn more about human biology.
Frontiers in Ovarian Cancer Science
This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades...
Surgery for Gynecologic Cancer
This comprehensive volume provides exhaustive interpretations of surgery for gynecologic cancer. In these chapters, expert authors expound the history, principles and indications, preoperative evaluations, techniques, morbidity, and the future prospects for each surgical procedure. Also included are comparisons of the training systems of gynecologic surgeons in Japan and the USA. Recently, minimally invasive surgeries such as laparoscopic and robotic approaches have been introduced into the gynecologic oncology field. Readers will be interested to know the history, advances, and current status of gynecologic surgery in Japan. This collection methodically broadens understanding of new surgical methods with quality assurance aimed at saving the cancer patient’s life, from the point of view of gynecologic oncologists. Thus the book benefits not only experienced gynecologists, but also young physicians and all medical oncologists who are involved in gynecologic cancers.
Placental And Endometrial Proteins: Basic And Clinical Aspects
In recent years there has been an enormous growth of interest in the proteins produced by the trophoblast and, most recently, the endometrium, since the knowledge of placental and endometrial proteins is essential for the understanding of the physiology of reproduction. This volume contains reports by 25 internationally renowned experts in this field presented at the 6th International Congress of Placental and Endometrial Proteins which was held in Nagoya, Japan, 1--3 December 1987. Additionally, these proceedings give a unique overview of research done in Japan by publishing over 70 papers by Japanese researchers.
Physics Briefs
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