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Targeting Protein-Protein Interactions by Small Molecules
This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Environmental Stressors and OxInflammatory Tissues Responses
Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of noncommunicable diseases. Accordingly, there is need for preclinical and clinical studies and comprehensive summary of major findings. This book is a state-of-the-art summary of these myriad severe life stressors. The chapters on the different pollutants focus on disease mechanisms (cardiovascular, neurological and metabolic disorders) and on oxidative stress and inflammation. The editors emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome, epigenetic pathways, and cognitive function by environmental stressors, and introduce the exposome concept while highlighting existing research gaps. Key Features: Links various environmental stressors to the incidence of noncommunicable diseases Includes chapters on airborne toxins, chemical pollutants, noise, and ultraviolet radiation stressors Contributions from an international team of leading researchers Summarizes the impacts of stressors on disease mechanisms
Gorgeous Consort Wants to Divorce
The moment he crossed over, he almost died because of a bowl of heart blood! What made things even more difficult was that the dregs Bai Lianqi went up to battle and tortured her, even trying to turn her into a pharmacist to treat the white lotus. Damn it! If a tiger doesn't show off its might, then this old lady is really a sick cat! He treated scum men and abused white lotuses, letting them know why flowers were so red with every step he took. However... What the hell was this prince, who crawled on the bed every night and pressed down on his body?
You Know My Love
After being killed, Su Xing accidentally transmigrated and became a lonely daughter in the Da Yun Sect. When he woke up, he was on the verge of death and even gave birth to a boy whose father was unknown ...
Proceedings
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Nonlinear Optical Phenomena and Applications
Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.
Yeast Biotechnology
This book is a printed edition of the Special Issue "Yeast Biotechnology" that was published in Fermentation
